BRCA2

Gene Symbol BRCA2
Entrez Gene 675
Alt Symbol BRCC2, BROVCA2, FACD, FAD, FAD1, FANCD, FANCD1, GLM3, PNCA2, XRCC11
Species Human
Gene Type protein-coding
Description breast cancer 2, early onset
Other Description BRCA1/BRCA2-containing complex, subunit 2|Fanconi anemia group D1 protein|breast and ovarian cancer susceptibility gene, early onset|breast cancer 2 tumor suppressor|breast cancer type 2 susceptibility protein
Swissprots Q13879 O00183 Q5TBJ7 O15008 P51587
Accessions AAG32681 AAG32682 AAG46030 AAK29432 AAN28944 AAN61409 AAN61410 AAN61411 AAN61412 AAN61413 AAN61414 AAN61415 AAN61416 AAN61417 AAN61418 AAN61419 AAN61420 AAN61421 AAN61422 AAN61426 AAN61427 AAN61428 AAN61429 AAN61430 AAN61431 AAN61432 AAN61433 AAN61434 AAN61435 AAN61436 AAN61437 AAQ97181 AAZ22546 ABJ90481 ACD01217 AIC83529 AIC83530 AIC83531 AIC83532 AIC83533 AIC83534 AIC83535 AIC83536 AIC83537 AIC83538 AIC83543 AIC83560 AIC83561 AIC83562 AIC83563 AIC83564 AIC83565 AIC83566 AIC83567 AIC83568 AIC83569 AIC83570 AIC83583 AIC83584 AIC83585 AIC83586 AIC83587 AIC83588 AIY60806 AKE50582 AKE50583 AKE50584 AKE50585 AKE50586 AKE50587 AKE50588 AKE50589 AKE50590 AKE50591 AKE50592 AKE50593 AKE50594 AKE50595 CAA64484 CAA97728 CAA98995 EAX08499 EAX08500 EAX08501 P51587 BC026160 BC047568 DQ897648 ABI74674 GU014835 ACX32322 JX480468 AFU88810 JX480469 AFU88811 JX480470 AFU88812 JX480471 AFU88813 JX480472 AFU88814 JX480473 AFU88815 JX480474 AFU88816 JX480475 AFU88817 JX480476 AFU88818 JX480477 AFU88819 JX480478 AFU88820 U43746 AAB07223 XM_011535203 XP_011533505 XM_011535204 XP_011533506 XM_011535205 XP_011533507 NM_000059 NP_000050
Function Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) s
Subcellular Location Nucleus {ECO:0000305|PubMed:21276791}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21276791}.
Tissue Specificity Highest levels of expression in breast and thymus, with slightly lower levels in lung, ovary and spleen.
Top Pathways Homologous recombination, Pancreatic cancer, Fanconi anemia pathway

BRCA2 CRISPR/Cas9 KO Plasmid (h) - sc-400700 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

BRCA2 HDR Plasmid (h) - sc-400700-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BRCA2 Double Nickase Plasmid (h) - sc-400700-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BRCA2 Double Nickase Plasmid (h2) - sc-400700-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BRCA2 CRISPR Activation Plasmid (h) - sc-400700-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

BRCA2 CRISPR Activation Plasmid (h2) - sc-400700-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

BRCA2 Lentiviral Activation Particles (h) - sc-400700-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BRCA2 Lentiviral Activation Particles (h2) - sc-400700-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

BRCA2 siRNA (h) - sc-29825 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

BRCA2 shRNA Plasmid (h) - sc-29825-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

BRCA2 shRNA (h) Lentiviral Particles - sc-29825-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

BRCA2 RNAi - H00000675-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU031451 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1613 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1613 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1225 from Sigma-Aldrich

Category ZFN Kit
Prices $6,000.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07087 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr07087

BRCA2 siRNA (Human) - CRH0469 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

BRCA2 - MBS8206072 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human BRCA2 (NM_000059.3) - SHH247558 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human BRCA2(NM_000059.3) - SHG104023 from Creative biogene

Category siRNA
Species Reactivities Human

Human BRCA2 siRNA - orb260971 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

BRCA2 shRNA Plasmid (Human) - CHH0469 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

BRCA2 miRNA 3'UTR clone - MiUTR1H-00938 from Creative biogene

Species Reactivities Human
Search more