| Gene Symbol |
PLCH2
|
| Entrez Gene |
9651
|
| Alt Symbol |
PLC-L4, PLC-eta2, PLCL4, PLCeta2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phospholipase C, eta 2
|
| Other Description |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2|phosphoinositide phospholipase C-eta-2|phosphoinositide phospholipase C-like 4|phospholipase C-eta2|phospholipase C-like 4|phospholipase C-like protein 4
|
| Swissprots |
B9DI80 Q3LUA8 Q86XJ2 Q8TEH5 Q8WUS6 A2VCM3 Q86YU7 Q86XU1 O75038
|
| Accessions |
EAW56101 EAW56102 EAW56103 EAW56104 O75038 AB007919 BAA32295 AK074149 BAB84975 AK122589 BAC56930 AK122591 BAC56932 BC019679 AAH19679 BC037356 BC043358 AAH43358 BC044630 BC050037 AAH50037 BC128207 AAI28208 BC128208 AAI28209 BC144620 BM971622 BX117873 DQ176850 ABA12209 XM_011542449 XP_011540751 XM_011542450 XP_011540752 XM_011542451 XP_011540753 XM_011542452 XP_011540754 XM_011542453 XP_011540755 XM_011542454 XP_011540756 XM_011542455 XP_011540757 XM_011542456 XP_011540758 XM_011542457 XP_011540759 XM_011542458 XP_011540760 XM_011542459 XP_011540761 XM_011542460 XP_011540762 XM_011546412 XP_011544714 XM_011546413 XP_011544715 XM_011546414 XP_011544716 XM_011546415 XP_011544717 XM_011546416 XP_011544718 XM_011546417 XP_011544719 XM_011546418 XP_011544720 XM_011546419 XP_011544721 XM_011546420 XP_011544722 XR_946803 XR_951574 NM_001303012 NP_001289941 NM_001303013 NP_001289942 NM_014638 NP_055453
|
| Function |
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm. Cell membrane. Note=Localized predominantly at the plasma membrane. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in retina and kidney. {ECO:0000269|PubMed:16107206}.
|
| Top Pathways |
Inositol phosphate metabolism
|