TXNRD1

Gene Symbol TXNRD1
Entrez Gene 7296
Alt Symbol GRIM-12, TR, TR1, TRXR1, TXNR
Species Human
Gene Type protein-coding
Description thioredoxin reductase 1
Other Description KM-102-derived reductase-like factor|gene associated with retinoic and IFN-induced mortality 12 protein|gene associated with retinoic and interferon-induced mortality 12 protein|oxidoreductase|thioredoxin reductase 1, cytoplasmic|thioredoxin reductase GRIM-12|thioredoxin reductase TR1
Swissprots E9PMY9 Q6VBP9 Q6VBP2 Q6FI31 Q76P53 Q99475 Q6YNQ1 Q8WVC8 B7Z904 Q16881 Q9UH79 Q9UES8 Q6VB41 Q6VB40 Q6VBQ0 B7Z1F4 Q6VB42 B7Z3Y8 Q7LA96 F5H780 Q6VBP4 Q6VBP5 Q6VBP3
Accessions AAZ67916 EAW97743 EAW97744 EAW97745 Q16881 AF077367 AAC69621 AF208018 AAF15900 AI097548 AJ001050 CAA04503 AK128515 BAC87474 AK129977 AK226071 AK293322 BAH11490 AK295067 BAH11961 AK296495 BAH12374 AK304241 BAH14140 AK308881 AK312262 BAG35193 AL701549 AY057105 AAL15432 AY344070 AY344071 AY344072 AY344074 AY344077 AY344080 AY344081 AAQ62461 AY344083 AAQ62462 AY344084 AAQ62463 AY344086 AAQ62464 AY344087 AAQ62465 AY344088 AY344089 AAQ62466 AY344092 AAQ62467 AY344093 AAQ62468 AY344095 AAQ62469 AY344096 AAQ62470 AY344669 AY344670 AAQ62471 AY344671 AY344672 AY344673 AAQ62472 AY344675 AY344679 AAQ62473 AY423378 BC018122 AAH18122 BC042974 BG772375 BT019640 AAV38446 CR536506 CAG38744 D88687 BAA13674 DA238692 DA319870 DA440625 DC351122 DC400503 DC401138 DC418649 S79851 AAB35418 X91247 CAA62629 NM_001093771 NP_001087240 NM_001261445 NP_001248374 NM_001261446 NP_001248375 NM_003330 NP_003321 NM_182729 NP_877393 NM_182742 NP_877419 NM_182743 NP_877420
Function Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid. {ECO:0000269|PubMed:15199063, ECO:0000269|PubMed:18042542, ECO:0000269|PubMed:8577704, ECO:0000269|PubMed:9774665}.
Subcellular Location Isoform 5: Cytoplasm.
Tissue Specificity Isoform 1 is expressed predominantly in Leydig cells (at protein level). Also expressed in ovary, spleen, heart, liver, kidney and pancreas and in a number of cancer cell lines. Isoform 4 is widely expressed with highest levels in kidney, testis, uterus, ovary, prostate, placenta and fetal liver. {ECO:0000269|PubMed:18042542, ECO:0000269|PubMed:8999974}.
Top Pathways Selenocompound metabolism, Pyrimidine metabolism

TRXR1 Antibody - 6925 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using TRXR1 Antibody.

TrxR1 (A-9) - sc-365658 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TrxR1 (A-9): sc-365658. Western blot analysis of TrxR1 expression in A549 whole cell lysate.

TrxR1 (B-2) - sc-28321 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TrxR1 (B-2): sc-28321. Immunofluorescence staining of methanol-fixed A549 cells showing cytoplasmic localization.

TrxR1 (A-20) - sc-18220 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TrxR1 (A-20): sc-18220. Western blot analysis of thioredoxin reductase expression in IB4 whole cell lysate.

TrxR1 (H-270) - sc-20147 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TrxR1 (H-270): sc-20147. Immunofluorescence staining of normal mouse intestine frozen section showing cytoplasmic staining.

TrxR1 (L-17) - sc-31057 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TrxR1 (L-17): sc-31057. Western blot analysis of TrxR1 expression in IB4 (A), Jurkat (B) and HuT 78 (C) whole cell lysates.

TrxR1 (T-16) - sc-31056 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TrxR1 (T-16): sc-31056. Western blot analysis of TrxR1 expression in non-transfected 293: sc-110760 (A), human TrxR1 transfected 293: sc-113112 (B) and A549 (C) whole cell lysates.

TrxR1 (19A1) - sc-58444 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
TrxR1 (19A1): sc-58444. Western blot analysis of TrxR1 expression in non-transfected: sc-110760 (A) and human TrxR1 transfected: sc-113112 (B) 293 whole cell lysates.

Anti-TXNRD1 antibody - ab155790 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-TXNRD1 antibody (ab155790) at 1/3000 dilution + MOLT4 whole cell lysate at 30 µg

Anti-TXNRD1 antibody [19A1] - ab16847 from Abcam

Prices $387.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 19A1

Anti-TXNRD1 antibody [5A5] - ab16851 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5A5
Immunoprecipitation analysis of HeLa cell lysates using ab16851.Lane 1: Input.Lane 2: Precipitates.

Anti-TXNRD1 antibody [EPNCIR129] - ab124954 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPNCIR129
All lanes : Anti-TXNRD1 antibody [EPNCIR129] (ab124954) at 1/1000 dilutionLane 1 : Mouse liver lysatesLane 2 : NIH 3T3 lysatesLane 3 : RAW264.7 lysatesLane 4 : Human fetal liver lysatesLane 5 : Rat liver lysatesLysates/proteins at 10 µg per lane.SecondaryGoat anti-Rabbit HRP at 1/2000 dilution

Anti-TXNRD1 antibody [EPR10204(B)] - ab151716 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR10204(B)
All lanes : Anti-TXNRD1 antibody [EPR10204(B)] (ab151716) at 1/1000 dilutionLane 1 : Jurkat cell lysateLane 2 : HeLa cell lysateLane 3 : A549 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-TXNRD1 antibody [EPR10205] - ab167411 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR10205
ab167411 showing +ve staining in Human normal kidney.

Anti-TRXR1 / TXNRD1 Antibody (aa137-150) - LS-C18077 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TRXR1 / TXNRD1 Antibody - LS-C132423 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-TRXR1 / TXNRD1 Antibody - LS-C132424 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-TRXR1 / TXNRD1 Antibody - LS-C189914 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TRXR1 / TXNRD1 Antibody - LS-C61892 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-TRXR1 / TXNRD1 Antibody (clone 19A1) - LS-C194665 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 19A1

Anti-TRXR1 / TXNRD1 Antibody (clone 7B2) - LS-C194667 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 7B2

Anti-TRXR1 / TXNRD1 Antibody (clone 5A5) - LS-C194666 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5A5

Anti-TRXR1 / TXNRD1 Antibody (clone 25B3.TR) - LS-C194668 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 25B3.TR

Anti-TRXR1 / TXNRD1 Antibody (clone 3A1.TR) - LS-C194669 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3A1.TR

Anti-TRXR1 / TXNRD1 Antibody (clone 2A1.TR) - LS-C194671 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2A1.TR
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