Gene Symbol | CEP89 |
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Entrez Gene | 84902 |
Alt Symbol | CCDC123, CEP123 |
Species | Human |
Gene Type | protein-coding |
Description | centrosomal protein 89kDa |
Other Description | centrosomal protein 123|centrosomal protein of 89 kDa|coiled-coil domain containing 123|coiled-coil domain-containing protein 123, mitochondrial |
Swissprots | B9EGA6 Q96ST8 Q8N5J8 |
Accessions | Q96ST8 AK001375 AK027546 BAB55190 AL832158 BC020195 AAH20195 BC029978 BC032307 AAH32307 BC136328 AAI36329 BE208545 BU196203 BU628988 BU630455 DA040903 DB539713 XM_005259344 XP_005259401 XM_005259346 XP_005259403 XM_011527425 XP_011525727 XR_935866 NM_032816 NP_116205 |
Function | Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity. {ECO:0000269|PubMed:23348840, ECO:0000269|PubMed:23575228}. |
Subcellular Location | Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Mitochondrion intermembrane space. Note=Localizes to the distal appendage region of the centriole, which anchors the mother centriole to the plasma membrane. |
CCDC123 CRISPR/Cas9 KO Plasmid (h) - sc-413723 from Santa Cruz Biotechnology
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CCDC123 HDR Plasmid (h) - sc-413723-HDR from Santa Cruz Biotechnology
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CCDC123 Double Nickase Plasmid (h) - sc-413723-NIC from Santa Cruz Biotechnology
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CCDC123 Double Nickase Plasmid (h2) - sc-413723-NIC-2 from Santa Cruz Biotechnology
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CCDC123 CRISPR Activation Plasmid (h) - sc-413723-ACT from Santa Cruz Biotechnology
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CCDC123 CRISPR Activation Plasmid (h2) - sc-413723-ACT-2 from Santa Cruz Biotechnology
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CCDC123 Lentiviral Activation Particles (h) - sc-413723-LAC from Santa Cruz Biotechnology
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CCDC123 Lentiviral Activation Particles (h2) - sc-413723-LAC-2 from Santa Cruz Biotechnology
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CCDC123 siRNA (h) - sc-97877 from Santa Cruz Biotechnology
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CCDC123 shRNA Plasmid (h) - sc-97877-SH from Santa Cruz Biotechnology
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CCDC123 shRNA (h) Lentiviral Particles - sc-97877-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU032041 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5468 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5468 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00338 from Sigma-Aldrich
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CEP89 siRNA (Human) - CRJ3680 from Cohesion Biosciences
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CEP89 - MBS8216139 from MyBioSource
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shRNA set against Human CEP89 (NM_032816.3) - SHH262037 from Creative biogene
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shRNA set against Human CCDC123(NM_032816.3) - SHG147131 from Creative biogene
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Human CEP89 siRNA - orb274181 from Biorbyt
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CEP89 shRNA Plasmid (Human) - CHJ3680 from Cohesion Biosciences
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CEP89 miRNA 3'UTR clone - MiUTR1H-01728 from Creative biogene
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