| Gene Symbol | CSNK2A1 |
|---|---|
| Entrez Gene | 1457 |
| Alt Symbol | CK2A1, CKII, CSNK2A3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | casein kinase 2, alpha 1 polypeptide |
| Other Description | CK II alpha 3|CK2 catalytic subunit alpha|casein kinase II alpha 1 polypeptide pseudogene|casein kinase II alpha 1 subunit|casein kinase II subunit alpha|protein kinase CK2 |
| Swissprots | P20426 D3DVV8 P19138 Q14013 Q5U065 P68400 B4DYS6 |
| Accessions | EAX10665 EAX10666 EAX10667 EAX10668 EAX10669 P68400 Q8NEV1 AB451279 BAG70093 AB451411 BAG70225 AK302583 BAG63838 AK312535 BAG35434 AU130091 AU131227 AU132198 AU133318 AW876962 AY735339 BC002615 BC011668 AAH11668 BC050036 AAH50036 BC053532 AAH53532 BC071167 AAH71167 BT019792 AAV38595 DQ354583 ABC86794 DQ893102 ABM84028 DQ896374 ABM87373 J02853 AAA56821 M55265 AAA35503 S53149 ABB72474 XM_011529175 XP_011527477 XM_011529176 XP_011527478 NM_001895 NP_001886 NM_177559 NP_808227 NM_177560 NP_808228 |
| Function | Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activat |
| Top Pathways | Wnt signaling pathway, Adherens junction, Tight junction, Ribosome biogenesis in eukaryotes, Measles |