| Gene Symbol |
DSG4
|
| Entrez Gene |
147409
|
| Alt Symbol |
CDGF13, CDHF13, HYPT6, LAH
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
desmoglein 4
|
| Other Description |
CDH family member 13|cadherin family member 13|desmoglein-4
|
| Swissprots |
A2RUI1 Q86SJ6 Q6Y9L9 Q8IXV4
|
| Accessions |
AAO47077 CAJ46939 CBX36877 CBY79749 CBY79768 CBY79787 CBY88743 CBY88771 CBY88790 CCA61679 CCA61698 CCA61717 CCA64044 CCA64165 CCA64184 CCA65394 CCA65425 CCD32754 EAX01256 EAX01257 Q86SJ6 AY168788 AAO43657 AY177664 AAO47078 AY227350 AAP45000 AY228236 AAP49811 BC039098 AAH39098 BC132907 AAI32908 BC132909 AAI32910 XM_011525827 XP_011524129 NM_001134453 NP_001127925 NM_177986 NP_817123
|
| Function |
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction, desmosome {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in skin, testis and prostate; less in salivary gland. In scalp follicles, present in the inner root sheath (IRS) and all layers of the matrix and precortex. {ECO:0000269|PubMed:12648213, ECO:0000269|PubMed:12705872}.
|
![Western Blot: Desmoglein 4 Overexpression Lysate (Adult Normal) [NBP2-05007] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Desmoglein 4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/24307_Desmoglein%25204%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-05007-img0001.jpg)