| Gene Symbol |
SUPT20H
|
| Entrez Gene |
55578
|
| Alt Symbol |
C13, C13orf19, FAM48A, FP757, P38IP, SPT20
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
suppressor of Ty 20 homolog (S. cerevisiae)
|
| Other Description |
family with sequence similarity 48, member A|protein FAM48A|transcription factor (p38 interacting protein)|transcription factor SPT20 homolog|tumor rejection antigen
|
| Swissprots |
E7ER46 Q8NEM7 Q71RF3 Q9Y6A6
|
| Accessions |
EAX08582 EAX08583 EAX08584 EAX08585 EAX08586 Q8NEM7 AF093250 AAD40550 AF370384 AAQ15220 AF445026 AAL38587 AJ130894 CAB62207 AK026091 AK027554 BAG51343 AK056121 AK093723 AK225376 AK292376 BAF85065 AK304227 BAG65097 BC001145 AAH01145 BC030686 AAH30686 DA593337 DQ891621 ABM82547 DQ896826 ABM87825 HY034874 XM_005266447 XP_005266504 XM_005266448 XP_005266505 XM_005266449 XP_005266506 XM_005266450 XP_005266507 XM_005266451 XP_005266508 XM_005266452 XP_005266509 XM_005266453 XP_005266510 XM_005266454 XP_005266511 XM_005266455 XP_005266512 XM_005266456 XP_005266513 XM_005266457 XP_005266514 XM_005266458 XP_005266515 XM_005266460 XP_005266517 XM_005266461 XP_005266518 XM_005266462 XP_005266519 XM_005266464 XP_005266521 XM_005266465 XP_005266522 XM_005266467 XP_005266524 XM_005266468 XP_005266525 XM_011535147 XP_011533449 XM_011535148 XP_011533450 XR_941624 XR_941626 NM_001014286 NP_001014308 NM_001278480 NP_001265409 NM_001278481 NP_001265410 NM_001278482 NP_001265411 NM_017569 NP_060039
|
| Function |
Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down- regulation of E-cadherin during gastrulation by regulating E- cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail (By similarity). Required for starvation- induced ATG9A trafficking during autophagy. {ECO:0000250, ECO:0000269|PubMed:19893488}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:19893488}.
|
| Tissue Specificity |
Highly expressed in testis, moderately in brain and pituitary gland. Expressed in several fetal tissues, including lung, brain, thymus and kidney. Expression is down- regulated in malignant prostate tissues. {ECO:0000269|PubMed:11340631}.
|