| Gene Symbol | AP3M1 |
|---|---|
| Entrez Gene | 26985 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | adaptor-related protein complex 3, mu 1 subunit |
| Other Description | AP-3 adapter complex mu3A subunit|AP-3 adaptor complex mu3A subunit|AP-3 complex subunit mu-1|adapter-related protein complex 3 mu-1 subunit|adapter-related protein complex 3 subunit mu-1|adaptor-related protein complex 3 subunit mu-1|clathrin adaptor complex AP3, mu-3A subunit|mu-adaptin 3A|mu3A-adaptin |
| Swissprots | Q5JQ12 Q9Y2T2 Q9H5L2 |
| Accessions | CAR81018 CBX84496 EAW54552 EAW54553 EAW54554 Q9Y2T2 AF092092 AAD20446 AI610802 AK001565 AK026983 BAB15614 AK299352 BAG61348 AK315597 AL133610 AL833820 CAD38682 AV722897 AW069033 BC026232 AAH26232 BC067127 AAH67127 BE706537 BM463185 BP230128 BU172918 BU430175 BU679701 DQ893112 ABM84038 DQ896386 ABM87385 EU176768 ABW03569 XM_006717763 XP_006717826 XM_011539635 XP_011537937 XM_011539636 XP_011537938 XR_945672 NM_012095 NP_036227 NM_207012 NP_996895 |
| Function | Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. |
| Subcellular Location | Golgi apparatus. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. {ECO:0000250}. |
| Top Pathways | Lysosome |
AP-3μ CRISPR/Cas9 KO Plasmid (h) - sc-411942 from Santa Cruz Biotechnology
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AP-3μ HDR Plasmid (h) - sc-411942-HDR from Santa Cruz Biotechnology
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AP-3μ Double Nickase Plasmid (h) - sc-411942-NIC from Santa Cruz Biotechnology
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AP-3μ Double Nickase Plasmid (h2) - sc-411942-NIC-2 from Santa Cruz Biotechnology
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AP-3μ CRISPR Activation Plasmid (h) - sc-411942-ACT from Santa Cruz Biotechnology
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AP-3μ CRISPR Activation Plasmid (h2) - sc-411942-ACT-2 from Santa Cruz Biotechnology
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AP-3μ Lentiviral Activation Particles (h) - sc-411942-LAC from Santa Cruz Biotechnology
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AP-3μ Lentiviral Activation Particles (h2) - sc-411942-LAC-2 from Santa Cruz Biotechnology
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AP-3μ siRNA (h) - sc-60177 from Santa Cruz Biotechnology
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AP-3μ shRNA Plasmid (h) - sc-60177-SH from Santa Cruz Biotechnology
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AP-3μ shRNA (h) Lentiviral Particles - sc-60177-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU098201 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3295 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3295 from Sigma-Aldrich
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AP3M1 siRNA (Human) - CRH8909 from Cohesion Biosciences
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AP3M1 - MBS8212688 from MyBioSource
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shRNA set against Human AP3M1 (NM_012095.4) - SHH237914 from Creative biogene
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shRNA set against Human AP3M1(NM_012095.4) - SHG063709 from Creative biogene
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Human AP3M1 siRNA - orb269411 from Biorbyt
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AP3M1 shRNA Plasmid (Human) - CHH8909 from Cohesion Biosciences
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AP3M1 miRNA 3'UTR clone - MiUTR1H-00444 from Creative biogene
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