| Gene Symbol | BCL6 |
|---|---|
| Entrez Gene | 604 |
| Alt Symbol | BCL5, BCL6A, LAZ3, ZBTB27, ZNF51 |
| Species | Human |
| Gene Type | protein-coding |
| Description | B-cell CLL/lymphoma 6 |
| Other Description | B-cell lymphoma 5 protein|B-cell lymphoma 6 protein|B-cell lymphoma 6 protein transcript|BCL-5|BCL-6|cys-his2 zinc finger transcription factor|lymphoma-associated zinc finger gene on chromosome 3|protein LAZ-3|zinc finger and BTB domain-containing protein 27|zinc finger protein 51|zinc finger transcription factor BCL6S |
| Swissprots | P41182 D3DNV5 B8PSA7 A7E241 |
| Accessions | AAA61320 EAW78140 EAW78141 P41182 AI624861 AK090890 AK304325 BAG65174 AK308162 AW337942 AW470156 BC142705 AAI42706 BC146796 BC150184 AAI50185 BX649185 CAE46203 CN401512 DB025893 DB079847 EU139066 ABX45135 EU883531 ACG60659 S67779 U00115 AAC50054 Z21943 CAA79937 XM_005247694 XP_005247751 XM_011513062 XP_011511364 NM_001130845 NP_001124317 NM_001134738 NP_001128210 NM_001706 NP_001697 NM_138931 |
| Function | Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6- binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physio |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:12504096, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:22113614, ECO:0000269|PubMed:23166356}. |
| Tissue Specificity | Expressed in germinal center T- and B-cells and in primary immature dendritic cells. {ECO:0000269|PubMed:10981963, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:15454082, ECO:0000269|PubMed:16142238, ECO:0000269|PubMed:16455075, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:9649500}. |
| Top Pathways | Transcriptional misregulation in cancer |