BCL6

Gene Symbol BCL6
Entrez Gene 604
Alt Symbol BCL5, BCL6A, LAZ3, ZBTB27, ZNF51
Species Human
Gene Type protein-coding
Description B-cell CLL/lymphoma 6
Other Description B-cell lymphoma 5 protein|B-cell lymphoma 6 protein|B-cell lymphoma 6 protein transcript|BCL-5|BCL-6|cys-his2 zinc finger transcription factor|lymphoma-associated zinc finger gene on chromosome 3|protein LAZ-3|zinc finger and BTB domain-containing protein 27|zinc finger protein 51|zinc finger transcription factor BCL6S
Swissprots P41182 D3DNV5 B8PSA7 A7E241
Accessions AAA61320 EAW78140 EAW78141 P41182 AI624861 AK090890 AK304325 BAG65174 AK308162 AW337942 AW470156 BC142705 AAI42706 BC146796 BC150184 AAI50185 BX649185 CAE46203 CN401512 DB025893 DB079847 EU139066 ABX45135 EU883531 ACG60659 S67779 U00115 AAC50054 Z21943 CAA79937 XM_005247694 XP_005247751 XM_011513062 XP_011511364 NM_001130845 NP_001124317 NM_001134738 NP_001128210 NM_001706 NP_001697 NM_138931
Function Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6- binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physio
Subcellular Location Nucleus {ECO:0000269|PubMed:12504096, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:22113614, ECO:0000269|PubMed:23166356}.
Tissue Specificity Expressed in germinal center T- and B-cells and in primary immature dendritic cells. {ECO:0000269|PubMed:10981963, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:15454082, ECO:0000269|PubMed:16142238, ECO:0000269|PubMed:16455075, ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:9649500}.
Top Pathways Transcriptional misregulation in cancer

BCL6 (D65C10) Rabbit mAb - 5650 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D65C10
Western blot analysis of extracts from various cell lines using BCL6 (D65C10) Rabbit mAb.

BCL6 Antibody - 4242 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of Ramos and A20 cell extracts using BCL6 Antibody.

Bcl-6 (H-12) - sc-365618 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Bcl-6 (H-12): sc-365618. Western blot analysis of Bcl-6 expression in Ramos whole cell lysate.

Bcl-6 (D-8) - sc-7388 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Bcl-6 (D-8): sc-7388. Immunofluorescence staining of methanol-fixed BJAB cells showing nuclear localization (A). Immunoperoxidase staining of formalin-fixed, paraffin-embedded human pancreas tumor showing nuclear staining (B).

Bcl-6 (7D1) - sc-130916 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rat
Clonality Monoclonal
Bcl-6 (7D1) FITC: sc-130916 FITC. Intracellular FCM analysis of fixed and permeabilized BJAB cells. Black line histogram represents the isotype control, normal rat IgG<sub>2a</sub>: sc-2831.

Bcl-6 (N-3) - sc-858 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Bcl-6 (N-3): sc-858. Western blot analysis of Bcl-6 expression in Ramos (A) and NAMALWA (B) whole cell lysates.

Bcl-6 (C-19) - sc-368 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Bcl-6 (C-19): sc-368. Western blot analysis of Bcl-6 expression in Ramos (A) and NAMALWA (B) whole cell lysates.

Bcl-6 (PG-B6P) - sc-56625 from Santa Cruz Biotechnology

Prices $279.00
Sizes 250 µl supernatant
Host Mouse
Clonality Monoclonal
Bcl-6 (PG-B6P): sc-56625. Western blot analysis of Bcl-6 expression in Ramos (A), Raji (B) and U-698-M (C) whole cell lysates.

Bcl-6 (0.N.26) - sc-70414 from Santa Cruz Biotechnology

Prices $279.00
Sizes 250 µl supernatant
Host Mouse
Clonality Monoclonal
Bcl-6 (0.N.26): sc-70414. Western blot analysis of Bcl-6 expression in Ramos (A), Raji (B), U-698-M (C) and BJAB (D) whole cell lysates.

Anti-bcl-6 antibody [EPR11410] - ab171967 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR11410
All lanes : Anti-bcl-6 antibody [EPR11410] (ab171967) at 1/1000 dilutionLane 1 : Ramos cell lysateLane 2 : Daudi cell lysateLane 3 : Raji cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilutiondeveloped using the ECL technique

Anti-bcl-6 antibody [EPR11410-43] - ab172610 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR11410-43
All lanes : Anti-bcl-6 antibody [EPR11410-43] (ab172610) at 1000 Lane 1 : Ramos cell lysateLane 2 : Daudi cell lysateLane 3 : Raji cell lysateLysates/proteins at 10 µg per lane.

Anti-Bcl6 antibody - ab19011 from Abcam

Prices $384.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-Bcl6 antibody - ab86861 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Bcl6 antibody (ab86861) at 1 µg/mlLane 1 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate Lane 2 : Ramos (Human Burkitt's lymphoma cell line) Whole Cell Lysate Lane 3 : K562 (Human erythromyeloblastoid leukemia cell line) Whole Cell Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Bcl6 antibody - ab203619 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Bcl6 antibody (ab203619) at 1/200 dilution + mouse brain lysateSecondaryGoat anti-rabbit IgG H+L conjugated HRP at 1/5000 dilution

Anti-Bcl6 antibody - ab41845 from Abcam

Prices $376.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
Ab41845 staining human Bcl6 in human tonsil by immunohistochemistry using formalin fixed, paraffin embedded tissue.

Anti-Bcl6 antibody - ab196492 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Bcl6 antibody (ab196492) at 1/500 dilutionLane 1 : 293 cell extractLane 2 : 293 cell extract with immunizing peptide

Anti-Bcl6 antibody - ab190753 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Bcl6 antibody (ab190753) at 1/500 dilution + 293 cell extract at 30 µg

Anti-Bcl6 antibody - ab13869 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Bcl6 antibody [EP529Y] - ab33901 from Abcam

Prices $381.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP529Y
Anti-Bcl6 antibody [EP529Y] (ab33901) at 1/2000 dilution + Daudi cell lysate

Anti-Bcl6 antibody [P1F6], prediluted - ab17402 from Abcam

Prices $370.00
Sizes 6 ml
Host Mouse
Clonality Monoclonal
Clone P1F6

Anti-Bcl6 antibody, prediluted - ab17109 from Abcam

Prices $370.00
Sizes 6 ml
Host Rabbit
Clonality Polyclonal

Anti-Bcl6 antibody, prediluted - ab41846 from Abcam

Prices $376.00
Sizes 7 ml
Host Rabbit
Clonality Polyclonal
Ab41846 staining human Bcl6 in human tonsil by immunohistochemsitry using formalin fixed - paraffin embedded tissue.

Anti-Bcl6 antibody [SP155] - C-terminal - ab183308 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone SP155
Immunohistochemical analysis of paraffin-embedded Human B-cell lymphoma tissue, labeling Bcl6 using ab183308 at a 1/100 dilution.

Bcl-6 Antibody - AF5046 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Western blot shows lysates of NIH‑3T3 mouse embryonic fibroblast cell line, HeLa human cervical epithelial carcinoma cell line, and 293T human embryonic kidney cell line. PVDF membrane was probed with 0.1 µg/mL of Mouse Bcl‑6 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5046) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). A specific band was detected for Bcl‑6 at approximately 100 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Bcl6 Polyclonal Antibody - bs-2734R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded human gastric carcinoma labeled with Rabbit Anti BCL-6/5 Polyclonal Antibody, Unconjugated (bs-2734R) at 1:200 followed by conjugation to the secondary antibody and DAB staining
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