DTNBP1

Gene Symbol DTNBP1
Entrez Gene 84062
Alt Symbol BLOC1S8, DBND, HPS7, My031, SDY
Species Human
Gene Type protein-coding
Description dystrobrevin binding protein 1
Other Description BLOC-1 subunit 8|Hermansky-Pudlak syndrome 7 protein|biogenesis of lysosomal organelles complex-1, subunit 8|biogenesis of lysosome-related organelles complex 1 subunit 8|dysbindin|dysbindin-1
Swissprots Q9H3J5 Q96NV2 Q5THY4 A8K3V3 Q96EV8 Q9H0U2 Q5THY3
Accessions EAW55359 EAW55360 EAW55361 EAW55362 EAW55363 EAW55364 Q96EV8 AF061734 AAG43145 AF394226 AAL46636 AI097393 AK054593 BAB70770 AK290718 BAF83407 AK310590 AL136637 CAB66572 AY265460 AAP91870 BC011912 AAH11912 BE793298 BQ056746 BQ108775 BX394617 EU831643 ACE87243 EU831727 ACE86561 EU832348 ACE87605 EU832433 ACE86918 XM_005249447 XP_005249504 XM_011514936 XP_011513238 XM_011514937 XP_011513239 NM_001271667 NP_001258596 NM_001271668 NP_001258597 NM_001271669 NP_001258598 NM_032122 NP_115498 NM_183040 NP_898861 NR_036448
Function Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic rel
Subcellular Location Isoform 3: Cytoplasm {ECO:0000269|PubMed:21390302}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:21390302}; Peripheral membrane protein {ECO:0000269|PubMed:21390302}; Cytoplasmic side {ECO:0000269|PubMed:21390302}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:21390302}; Peripheral membrane protein {ECO:0000269|PubMed:21390302}; Cytoplasmic side {ECO:0000269|PubMed:21390302}. Endosome membrane {ECO:0000269|PubMed:21390302}; Peripheral membrane protein {ECO:0000269|PubMed:21390302}; Cytoplasmic side {ECO:0000269|PubMed:21390302}. Melanosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000269|PubMed:21390302}. Endoplasmic reticulum {ECO:0000250}. Note=Exclusivley cytoplasmic. Predominantly found in the postsynaptic density (PSD). Little association with synaptic vesicles. The BLOC-1 complex associates with the BLOC-2 complex in early e
Tissue Specificity Detected in brain, in neurons and in neuropil. Isoform 1 is expressed in the cerebral cortex, and hippocampal frontal (HF). Specific expression in the posterior half of the superior temporal gyrus (pSTG). Higher expression of isoform 2 and 3 in the HF than in the pSTG while isoform 1 shows no difference in expression in these areas. In the HF, detected in dentate gyrus (DG) and in pyramidal cells of hippocampus CA2 and CA3 (at protein level). Expressed in all principal neuronal populations of the HF, namely pyramidal neurons in the subiculum and CA1-3, granule cells in the dense cell layer of the DG (DGg), and polymorph cells in the hilus of the DG (DGh). Maximal levels in CA2, CA3, and DGh. Isoform 2 not expressed in the cerebral cortex. {ECO:0000269|PubMed:16980328}.

Dysbindin Antibody - 4611 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of HeLa cells, untransfected or transfected with a construct overexpressing dysbindin, and other cell lines using Dysbindin Antibody.

Dysbindin (B-5) - sc-398872 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Dysbindin (B-5): sc-398872. Western blot analysis of Dysbindin expression in non-transfected: sc-117752 (A) and mouse Dysbindin transfected: sc-119875 (B) 293T whole cell lysates.

Dysbindin (D-8) - sc-390626 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Dysbindin (D-8): sc-390626. Western blot analysis of Dysbindin expression in non-transfected 293T: sc-117752 (A), mouse transfected 293T: sc-119875 (B), HeLa (C) and SK-N-SH (D) whole cell lysates.

Dysbindin (D-20) - sc-46931 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Dysbindin (D-20): sc-46931. Western blot analysis of Dysbindin expression in HeLa (A), SK-N-SH (B), Hep G2 (C) and IMR-32 (D) whole cell lysates.

Dysbindin (H-90) - sc-67171 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Dysbindin (H-90): sc-67171. Western blot analysis of Dysbindin expression in 293T whole cell lysate.

Dysbindin (B-13) - sc-46930 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Dysbindin (B-13): sc-46930. Western blot analysis of Dysbindin 1 expression in non-transfected: sc-117752 (A) and human Dysbindin 1 transfected: sc-177154 (B) 293T whole cell lysates.

Anti-Dysbindin antibody - ab175084 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human esophageal cancer tissue labelling Dysbindin with ab175084 at 1/100. Magnification: 200x.

Anti-Dysbindin antibody - ab118795 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Dysbindin antibody (ab118795) at 1 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : 293T whole cell lysate at 50 µgLane 4 : Jurkat whole cell lysate at 50 µgdeveloped using the ECL technique

Anti-Dysbindin antibody - ab130291 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Dysbindin antibody (ab130291) + Hela cell line lysates at 35 µg

Anti-Dysbindin antibody - ab54548 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Dysbindin antibody [EPR7041] - ab133652 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7041
All lanes : Anti-Dysbindin antibody [EPR7041] (ab133652) at 1/1000 dilutionLane 1 : 293T cell lysateLane 2 : HeLa cell lysateLane 3 : Jurkat cell lysateLane 4 : Human fetal lung tissue lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-Rabbit HRP at 1/2000 dilution

Anti-Dysbindin antibody [EPR7042(B)] - ab124967 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7042(B)
All lanes : Anti-Dysbindin antibody [EPR7042(B)] (ab124967) at 1/1000 dilutionLane 1 : SH-SY5Y cell lysateLane 2 : HeLa cell lysateLane 3 : HepG2 cell lysate Lane 4 : 293T cell lysate Lysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-DTNBP1 / Dysbindin Antibody - LS-C331601 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded rat lung using DTNBP1 antibody at dilution of 1:100 (200x lens).

Anti-DTNBP1 / Dysbindin Antibody (C-Terminus, clone EPR7042(B)) - LS-C138881 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7042(B)
Western blot analysis on (A) SH-SY5Y, (B) HeLa, (C) HepG2, and (D) 293T cell lysates using anti-Dysbindin antibody.

Anti-DTNBP1 / Dysbindin Antibody (aa120-170) - LS-C203264 from LifeSpan Bioscience

Prices $245.00
Sizes 40 µg
Host Rabbit
Clonality Polyclonal

Anti-DTNBP1 / Dysbindin Antibody (aa9-38, AP) - LS-C256324 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DTNBP1 / Dysbindin Antibody (aa9-38, APC) - LS-C256325 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DTNBP1 / Dysbindin Antibody (aa9-38, Biotin) - LS-C256326 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DTNBP1 / Dysbindin Antibody (aa191-240) - LS-C201749 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human HepG2. DTNBP1 antibody dilution 1.0 ug/ml.

Anti-DTNBP1 / Dysbindin Antibody (aa9-38, FITC) - LS-C256327 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DTNBP1 / Dysbindin Antibody (aa9-38, Azide-free, HRP) - LS-C256328 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DTNBP1 / Dysbindin Antibody (C-Terminus, APC) - LS-C276889 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DTNBP1 / Dysbindin Antibody (C-Terminus, AP) - LS-C276888 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DTNBP1 / Dysbindin Antibody (C-Terminus, Biotin) - LS-C276890 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DTNBP1 / Dysbindin Antibody (C-Terminus, FITC) - LS-C276891 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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