| Gene Symbol |
BRSK2
|
| Entrez Gene |
9024
|
| Alt Symbol |
C11orf7, PEN11B, SAD1, SADA, STK29
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
BR serine/threonine kinase 2
|
| Other Description |
BR serine/threonine-protein kinase 2|brain-selective kinase 2|brain-specific serine/threonine-protein kinase 2|protein kinase SAD1B|serine/threonine-protein kinase 29|serine/threonine-protein kinase BRSK2|serine/threonine-protein kinase SAD-A
|
| Swissprots |
Q8TB60 B3KVE9 E9PLM7 Q6ZMQ4 Q8IWQ3 Q5J5B4 O60843 O95099
|
| Accessions |
EAX02436 EAX02437 EAX02438 EAX02439 EAX02440 EAX02441 EAX02442 EAX02443 EAX02444 Q8IWQ3 AF020089 AAD09654 AF533876 AAP97723 AF533877 AAP97724 AF533878 AAP97725 AF533879 AAP97726 AF533880 AAP97727 AJ006701 CAA07196 AK074411 AK122851 BAG53761 AK123356 BAC85593 AK131534 BAD18671 AK297211 BAG59695 AK297306 BAG59772 AY166857 AAN87839 AY505125 AAS86443 BC017182 BC024291 AAH24291 BC152769 AAI52770 BG395884 DA059153 DQ600947 DR001379 XM_005253218 XP_005253275 XM_005253220 XP_005253277 XM_006718374 XP_006718437 XM_006718376 XP_006718439 XM_011520460 XP_011518762 XM_011520461 XP_011518763 XM_011520462 XP_011518764 XM_011520463 XP_011518765 XM_011520464 XP_011518766 XM_011520465 XP_011518767 XR_242831 XR_930923 XR_930924 XR_930925 XR_930926 XR_930927 NM_001256627 NP_001243556 NM_001256629 NP_001243558 NM_001256630 NP_001243559 NM_001282218 NP_001269147 NM_003957 NP_003948 NR_046331
|
| Function |
Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945)
|
| Subcellular Location |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear region. Endoplasmic reticulum. Note=Detected at centrosomes during mitosis. Localizes to the endoplasmic reticulum in response to stress caused by tunicamycin.
|
| Tissue Specificity |
Detected in pancreas islets (at protein level). {ECO:0000269|PubMed:22798068}.
|