| Gene Symbol |
CLTCL1
|
| Entrez Gene |
8218
|
| Alt Symbol |
CHC22, CLH22, CLTCL, CLTD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
clathrin, heavy chain-like 1
|
| Other Description |
CLH-22|Clathrin, heavy polypeptide D|clathrin heavy chain 2|clathrin heavy chain on chromosome 22|clathrin, heavy polypeptide-like 1
|
| Swissprots |
Q15808 Q14017 Q15809 B7Z7U5 P53675
|
| Accessions |
EAX03046 EAX03047 P53675 AK125929 AK294147 BAH11683 AK295264 BAH12020 AK302506 BAH13731 AY927418 BC113030 AAI13031 BC143977 BC143979 BC166681 AAI66681 BF893495 BP281338 CN428107 L77568 U41763 AAC50494 U60802 AAB40908 X95486 CAA64752 X95487 CAA64753 XM_005277800 XP_005277857 XM_005277801 XP_005277858 XM_006724328 XP_006724391 XM_011530395 XP_011528697 XM_011530396 XP_011528698 XM_011530397 XP_011528699 XM_011530398 XP_011528700 XM_011530399 XP_011528701 XM_011530400 XP_011528702 XM_011530401 XP_011528703 XR_937923 XR_937924 NM_001835 NP_001826 NM_007098 NP_009029
|
| Function |
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Membrane, coated pit {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Cytoplasmic face of coated pits and vesicles. {ECO:0000250}.
|
| Tissue Specificity |
Maximal levels in skeletal muscle. High levels in heart and testis. Low expression detected in all other tissues.
|
| Top Pathways |
Huntington's disease, Endocytosis, Lysosome, Bacterial invasion of epithelial cells, Endocrine and other factor-regulated calcium reabsorption
|