CACNA1A

Gene Symbol	CACNA1A
Entrez Gene	773
Alt Symbol	APCA, BI, CACNL1A4, CAV2.1, EA2, FHM, HPCA, MHP, MHP1, SCA6
Species	Human
Gene Type	protein-coding
Description	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Other Description	brain calcium channel 1|brain calcium channel I|calcium channel, L type, alpha-1 polypeptide|voltage-dependent P/Q-type calcium channel subunit alpha-1A|voltage-gated calcium channel subunit alpha Cav2.1
Swissprots	J3KP41 P78510 Q16290 Q99793 Q9UDC4 Q99790 O00555 Q9NS88 Q99791 Q99792 P78511 Q92690
Accessions	AAC26839 AAD38386 AAF03935 EAW84361 EAW84362 EAW84363 EAW84364 EAW84365 EAW84366 O00555 AB035726 BAA94765 AB035727 BAA94766 AF004883 AAB61612 AF004884 AAB61613 AF100774 AAC77460 BC028611 BQ340521 EU016197 ABV80232 FJ040507 ACH89974 S76537 AAB33068 U06702 U79663 AAB49674 U79664 AAB49675 U79665 AAB49676 U79666 AAB64179 U79667 AAB49677 U79668 AAB49678 X99897 CAA68172 NM_000068 NP_000059 NM_001127221 NP_001120693 NM_001127222 NP_001120694 NM_001174080 NP_001167551 NM_023035 NP_075461
Function	Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin- IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA).
Subcellular Location	Membrane; Multi-pass membrane protein.
Tissue Specificity	Brain specific; mainly found in cerebellum, cerebral cortex, thalamus and hypothalamus. Expressed in the small cell lung carcinoma cell line SCC-9. No expression in heart, kidney, liver or muscle. Purkinje cells contain predominantly P- type VSCC, the Q-type being a prominent calcium current in cerebellar granule cells. {ECO:0000269|PubMed:1335101}.
Top Pathways	Retrograde endocannabinoid signaling, Morphine addiction, Nicotine addiction, Long-term depression, Dopaminergic synapse

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

P/Q-type Ca ++ CP α1A (C-20) - sc-16228 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

P/Q-type Ca ++ CP α1A (C-2) - sc-390004 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

P/Q-type Ca ++ CP α1A (D-20) - sc-16227 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

P/Q-type Ca ++ CP α1A (H-90) - sc-28619 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Anti-CACNA1A antibody - ab81011 from Abcam Host Rabbit Clonality Polyclonal

Anti-CACNA1A antibody [EPR4458(N)] - ab181371 from Abcam Prices $379.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR4458(N)

Anti-CACNA1A antibody - N-terminal - ab191140 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-CACNA1A / Cav2.1 Antibody (aa717-1190) - LS-C140629 from LifeSpan Bioscience Prices $395.00 Sizes 10 blot Host Rabbit Clonality Polyclonal

Anti-CACNA1A / Cav2.1 Antibody (clone 7H7) - LS-C179413 from LifeSpan Bioscience Prices $350.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 7H7

Anti-CACNA1A / Cav2.1 Antibody (aa430-447) - LS-C313383 from LifeSpan Bioscience Prices $305.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-CACNA1A / Cav2.1 Antibody - LS-C26745 from LifeSpan Bioscience Prices $330.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

CACNA1A Antibody - NBP1-20102 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CACNA1A Antibody - NBP2-38049 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CACNA1A/Cav2.1 Polyclonal Antibody - bs-3930R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-CACNA1A antibody produced in rabbit - SAB4301067 from Sigma-Aldrich Prices $230.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

hpca antibody - zf125038 from GeneTex Host Rabbit Clonality Polyclonal

CACNA1A antibody - orb5779 from Biorbyt Prices $60.00, $128.00, $255.00, $340.00 Sizes 5 μg (Trial size), 20 μg (Trial size), 100 μg, 200 μg Host Rabbit Clonality Polyclonal

Anti -HPCA (Neuron-specific Calcium-binding Protein Hippocalcin, Calcium-binding ProteinBDR-2, BDR2) - 128054 from USBiological Life Science Host Mouse Clonality Polyclonal

CACNA1A/Cav2.1 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-3930R-A350 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CACNA1A/Cav2.1 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-3930R-A488 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CACNA1A/Cav2.1 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-3930R-A555 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CACNA1A/Cav2.1 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-3930R-A647 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CACNA1A/Cav2.1 Polyclonal Antibody, Cy3 Conjugated - bs-3930R-Cy3 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CACNA1A/Cav2.1 Polyclonal Antibody, Cy5 Conjugated - bs-3930R-Cy5 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CACNA1A/Cav2.1 Polyclonal Antibody, Cy5.5 Conjugated - bs-3930R-Cy5.5 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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