PIR

Gene Symbol	PIR
Entrez Gene	8544
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	pirin (iron-binding nuclear protein)
Other Description	pirin|probable quercetin 2,3-dioxygenase PIR|probable quercetinase
Swissprots	Q6FHD2 O00625 Q5U0G0
Accessions	CAD33303 EAW98886 EAW98887 EAW98888 O00625 AK309656 BC002517 AAH02517 BT019583 AAV38390 BT019584 AAV38391 CR541822 CAG46621 DA686501 DQ891941 ABM82867 DQ895128 ABM86054 DT217415 Y07867 CAA69194 Y07868 CAA69195 NM_001018109 NP_001018119 NM_003662 NP_003653
Function	Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro). {ECO:0000269|PubMed:17288615, ECO:0000269|PubMed:20010624, ECO:0000269|PubMed:20711196, ECO:0000269|PubMed:23716661}.
Subcellular Location	Nucleus. Cytoplasm. Note=Predominantly localized in dot-like subnuclear structures. Cytoplasmic localization of PIR seems to positively correlate with melanoma progression.
Tissue Specificity	Highly expressed in a subset of melanomas. Detected at very low levels in most tissues (at protein level). Expressed in all tissues, with highest level of expression in heart and liver. {ECO:0000269|PubMed:20089166, ECO:0000269|PubMed:9079676}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Pirin full length protein - ab123170 from Abcam Category Protein Source E. coli Species Human

Pirin peptide - ab45602 from Abcam Category Peptide

Pirin / PIR Antibody Blocking Peptide - LS-E25749 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Pirin / PIR Antibody Blocking Peptide - LS-E11906 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Pirin / PIR Antibody Blocking Peptide - LS-E11907 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Pirin Recombinant Protein - H00008544-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Pirin Protein - NBP1-99104 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli Species Human

Pirin blocking peptide - GTX89691-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse

Human PIR protein - orb169033 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 25 μg Species Human

PIR protein (His tag) - 80R-2157 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

Pirin Peptide - AC21-0578-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Pirin / PIR (1-290, His-tag) - AR50238PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

Pirin / PIR (1-290, His-tag) - AR50238PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

Pirin / PIR - H00008544-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Pirin / PIR - H00008544-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PIR, 1-290aa, Human, His tag, E.coli - 01-P1413 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

Pirin Peptide - 46-193P from ProSci Category Peptide Species Human

PIR fusion protein - Ag0330 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

PIR Human - PRPS-1047 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 25 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human PIR Protein - BP002907-PRO-1040 from Syd Labs Category Protein Prices $160.00, $2,700.00 Sizes 25 µg, 1 mg Source E. coli-derived. Species Human

Recombinant Human PIR, GST-tagged - PIR-1730H from Creative Biomart Category Protein Source E.coli Species Human

PIR 1-290aa - CMB-1246 from Reagent Proteins Category Protein Prices $469.00, $889.00 Sizes 100.00 µg, 500 µg Source E.coli Species Human

Recombinant Pirin (PIR) - RPC250Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Pirin (PIR) - RPC250Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Pirin(PIR) - CSB-YP018032HU CSB-EP018032HU CSB-BP018032HU CSB-MP018032HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

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