BRDT

Gene Symbol	BRDT
Entrez Gene	676
Alt Symbol	BRD6, CT9
Species	Human
Gene Type	protein-coding
Description	bromodomain, testis-specific
Other Description	RING3-like protein|bromodomain testis-specific protein|cancer/testis antigen 9
Swissprots	Q8IWI6 Q05DQ4 O14789 D3DT32 Q58F21 B7Z890 Q6P5T1 Q7Z4A6 A6NF68 B7ZAX7 B7Z811
Accessions	EAW73106 EAW73107 EAW73108 EAW73109 EAW73110 EAW73111 Q58F21 AF019085 AAB87862 AK302758 BAH13797 AK303008 BAH13876 AK316442 BAH14813 AY338951 AAQ16198 BC005281 AAH05281 BC017582 AAH17582 BC028126 BC038844 BC047900 AAH47900 BC062700 AAH62700 BC111927 AAI11928 BC118498 AAI18499 BG717291 BX648135 DB072781 DC401352 DC402057 XM_006710853 XP_006710916 XM_006710854 XP_006710917 XM_006710855 XP_006710918 XM_006710856 XP_006710919 XM_006710857 XP_006710920 XM_011542032 XP_011540334 XM_011542033 XP_011540335 XM_011542034 XP_011540336 XM_011542035 XP_011540337 XM_011542036 XP_011540338 NM_001242805 NP_001229734 NM_001242806 NP_001229735 NM_001242807 NP_001229736 NM_001242808 NP_001229737 NM_001242810 NP_001229739 NM_001726 NP_001717 NM_207189 NP_997072
Function	Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA. Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3'-UTR truncation of specific mRNAs in post-meiotic spermatids. Required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin. {ECO:0000269|PubMed:15647849, ECO:0000269|PubMed:22901802, ECO:0000269|PubMed:9367677}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:20538714, ECO:0000269|PubMed:22901802, ECO:0000269|PubMed:22971749}. Note=Detected on chromatin.
Tissue Specificity	Testis-specific. A 3-fold higher expression is seen in adult testis than in embryo testis. Expression seems to be correlated with histone H4 hyperacetylation during the haploid phase of spermatogenesis (spermiogenesis). No expression, or very low expression is seen in patients' testes with abnormal spermatogenesis. Expressed in cancers such as non-small cell lung cancer and squamous cell carcinomas of the head and neck as well as of esophagus, but not in melanoma or in cancers of the colon, breast, kidney and bladder. {ECO:0000269|PubMed:10704737, ECO:0000269|PubMed:15647849, ECO:0000269|PubMed:9367677}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

BRDT CRISPR/Cas9 KO Plasmid (h) - sc-416531 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

BRDT HDR Plasmid (h) - sc-416531-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

BRDT Double Nickase Plasmid (h) - sc-416531-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

BRDT Double Nickase Plasmid (h2) - sc-416531-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

BRDT CRISPR Activation Plasmid (h) - sc-416531-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

BRDT CRISPR Activation Plasmid (h2) - sc-416531-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

BRDT Lentiviral Activation Particles (h) - sc-416531-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

BRDT Lentiviral Activation Particles (h2) - sc-416531-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

BRDT siRNA (h) - sc-60286 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

BRDT shRNA Plasmid (h) - sc-60286-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

BRDT shRNA (h) Lentiviral Particles - sc-60286-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

BRDT RNAi - H00000676-R05 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU116781 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK0195 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0196 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0197 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN4055 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4055 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

BRDT siRNA (Human) - CRH0470 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

BRDT RNAi - H00000676-R06 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

BRDT - MBS8228403 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human BRDT (NM_001726.3) - SHH247670 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human BRDT(NM_001726.3) - SHG104421 from Creative biogene Category siRNA Species Reactivities Human

BRDT shRNA Plasmid (Human) - CHH0470 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

BRDT miRNA 3'UTR clone - MiUTR1H-00943 from Creative biogene Species Reactivities Human

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