Gene Symbol | PIK3R4 |
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Entrez Gene | 30849 |
Alt Symbol | VPS15, p150 |
Species | Human |
Gene Type | protein-coding |
Description | phosphoinositide-3-kinase, regulatory subunit 4 |
Other Description | PI3-kinase p150 subunit|PI3-kinase regulatory subunit 4|phosphatidylinositol 3-kinase-associated p150|phosphoinositide 3-kinase adaptor protein|phosphoinositide 3-kinase regulatory subunit 4|phosphoinositide-3-kinase, regulatory subunit 4, p150 |
Swissprots | Q2TBF4 Q99570 |
Accessions | CAV30715 EAW79222 Q99570 AK314219 BAG36893 BC009899 BC017332 BC057239 BC069191 BC110318 AAI10319 BC127105 AAI27106 BC127106 AAI27107 BP359657 Y08991 CAA70176 NM_014602 NP_055417 |
Function | Regulatory subunit of the PI3K complex. May regulate membrane trafficking late in the endocytic pathway. |
Subcellular Location | Late endosome {ECO:0000269|PubMed:14617358}. Note=Localizes also to discrete punctae along the ciliary axoneme. {ECO:0000250}. |
Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:8999962}. |
Top Pathways | Regulation of autophagy |
p150 CRISPR/Cas9 KO Plasmid (h) - sc-405483 from Santa Cruz Biotechnology
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p150 HDR Plasmid (h) - sc-405483-HDR from Santa Cruz Biotechnology
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p150 Double Nickase Plasmid (h) - sc-405483-NIC from Santa Cruz Biotechnology
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p150 Double Nickase Plasmid (h2) - sc-405483-NIC-2 from Santa Cruz Biotechnology
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p150 CRISPR Activation Plasmid (h) - sc-405483-ACT from Santa Cruz Biotechnology
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p150 CRISPR Activation Plasmid (h2) - sc-405483-ACT-2 from Santa Cruz Biotechnology
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p150 Lentiviral Activation Particles (h) - sc-405483-LAC from Santa Cruz Biotechnology
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p150 Lentiviral Activation Particles (h2) - sc-405483-LAC-2 from Santa Cruz Biotechnology
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p150 siRNA (h) - sc-43986 from Santa Cruz Biotechnology
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p150 shRNA Plasmid (h) - sc-43986-SH from Santa Cruz Biotechnology
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p150 shRNA (h) Lentiviral Particles - sc-43986-V from Santa Cruz Biotechnology
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PIK3R4 RNAi - H00030849-R01V from Novus Biologicals
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PIK3R4 RNAi - H00030849-R02 from Novus Biologicals
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MISSION® esiRNA - EHU000231 from Sigma-Aldrich
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MISSION® siRNA - SIHK1674 from Sigma-Aldrich
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MISSION® siRNA - SIHK1675 from Sigma-Aldrich
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MISSION® siRNA - SIHK1673 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2402 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2402 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12997 from Sigma-Aldrich
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PIK3R4 siRNA (Human) - CRH9359 from Cohesion Biosciences
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shRNA set against Human PIK3R4 (NM_014602.2) - SHH375808 from Creative biogene
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shRNA set against Human PIK3R4(NM_014602.2) - SHR115076 from Creative biogene
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PIK3R4 shRNA Plasmid (Human) - CHH9359 from Cohesion Biosciences
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PIK3R4 miRNA 3'UTR clone - MiUTR1H-07914 from Creative biogene
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