Gene Symbol | CYP11A1 |
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Entrez Gene | 1583 |
Alt Symbol | CYP11A, CYPXIA1, P450SCC |
Species | Human |
Gene Type | protein-coding |
Description | cytochrome P450, family 11, subfamily A, polypeptide 1 |
Other Description | cholesterol 20-22 desmolase|cholesterol monooxygenase (side-chain cleaving)|cholesterol side-chain cleavage enzyme, mitochondrial|cytochrome P450 11A1|cytochrome P450(scc)|cytochrome P450, subfamily XIA (cholesterol side chain cleavage)|cytochrome P450C11A1|steroid 20-22-lyase |
Swissprots | Q15081 A8K8D5 P05108 Q8N1A7 G3XAD7 Q16805 B3KPU8 |
Accessions | ABC86898 CAA28965 CAA32471 EAW99341 EAW99342 P05108 AI149078 AK056794 BAG51810 AK225715 AK292300 BAF84989 AK292301 BAF84990 AK293204 BAG56744 AK293211 BAG56751 AK300178 BAG61957 AK310362 AY603498 BC032329 AAH32329 BX398579 DA010417 DQ891578 ABM82504 DQ894771 ABM85697 M14565 AAA52162 M28253 AAA36404 NM_000781 NP_000772 NM_001099773 NP_001093243 |
Function | Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone. {ECO:0000269|PubMed:21636783}. |
Subcellular Location | Mitochondrion membrane. |
Top Pathways | Steroid hormone biosynthesis, Ovarian steroidogenesis |
CYP11A1 CRISPR/Cas9 KO Plasmid (h) - sc-401269 from Santa Cruz Biotechnology
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CYP11A1 HDR Plasmid (h) - sc-401269-HDR from Santa Cruz Biotechnology
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CYP11A1 Double Nickase Plasmid (h) - sc-401269-NIC from Santa Cruz Biotechnology
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CYP11A1 Double Nickase Plasmid (h2) - sc-401269-NIC-2 from Santa Cruz Biotechnology
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CYP11A1 CRISPR Activation Plasmid (h) - sc-401269-ACT from Santa Cruz Biotechnology
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CYP11A1 CRISPR Activation Plasmid (h2) - sc-401269-ACT-2 from Santa Cruz Biotechnology
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CYP11A1 Lentiviral Activation Particles (h) - sc-401269-LAC from Santa Cruz Biotechnology
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CYP11A1 Lentiviral Activation Particles (h2) - sc-401269-LAC-2 from Santa Cruz Biotechnology
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CYP11A1 siRNA (h) - sc-41496 from Santa Cruz Biotechnology
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CYP11A1 shRNA Plasmid (h) - sc-41496-SH from Santa Cruz Biotechnology
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CYP11A1 shRNA (h) Lentiviral Particles - sc-41496-V from Santa Cruz Biotechnology
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CYP11A1 RNAi - H00001583-R01 from Novus Biologicals
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MISSION® esiRNA - EHU143581 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6872 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6872 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00473 from Sigma-Aldrich
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CYP11A1 siRNA (Human) - CRH1112 from Cohesion Biosciences
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CYP11A1 - MBS8206848 from MyBioSource
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CYP11A1 CRISPR/Cas9 KO Plasmid (h2) - sc-401269-KO-2 from Santa Cruz Biotechnology
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CYP11A1 HDR Plasmid (h2) - sc-401269-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human CYP11A1 (NM_000781.2) - SHH272805 from Creative biogene
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shRNA set against Human CYP11A1(NM_000781.2) - SHG215335 from Creative biogene
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Human CYP11A1 siRNA - orb261614 from Biorbyt
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CYP11A1 shRNA Plasmid (Human) - CHH1112 from Cohesion Biosciences
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CYP11A1 miRNA 3'UTR clone - MiUTR1H-02605 from Creative biogene
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