Gene Symbol | AFP |
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Entrez Gene | 174 |
Alt Symbol | AFPD, FETA, HPAFP |
Species | Human |
Gene Type | protein-coding |
Description | alpha-fetoprotein |
Other Description | alpha-1-fetoprotein|alpha-fetoglobulin |
Swissprots | P02771 B2RBU3 |
Accessions | AAA51674 AAA51675 AAB58754 CAA79592 EAX05681 P02771 AF484525 AF484526 AI336986 AK297669 BAG60031 AK297674 BAG60036 AK314817 BAG37340 BC027881 AAH27881 DQ890942 ABM81868 DQ894103 ABM85029 V01514 CAA24758 XM_011531704 XP_011530006 NM_001134 NP_001125 |
Function | Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties. |
Subcellular Location | Secreted. |
Tissue Specificity | Plasma. Synthesized by the fetal liver and yolk sac. |
Top Pathways | Hippo signaling pathway |
AFP CRISPR/Cas9 KO Plasmid (h) - sc-400355 from Santa Cruz Biotechnology
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AFP HDR Plasmid (h) - sc-400355-HDR from Santa Cruz Biotechnology
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AFP Double Nickase Plasmid (h) - sc-400355-NIC from Santa Cruz Biotechnology
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AFP Double Nickase Plasmid (h2) - sc-400355-NIC-2 from Santa Cruz Biotechnology
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AFP CRISPR Activation Plasmid (h) - sc-400355-ACT from Santa Cruz Biotechnology
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AFP CRISPR Activation Plasmid (h2) - sc-400355-ACT-2 from Santa Cruz Biotechnology
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AFP Lentiviral Activation Particles (h) - sc-400355-LAC from Santa Cruz Biotechnology
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AFP Lentiviral Activation Particles (h2) - sc-400355-LAC-2 from Santa Cruz Biotechnology
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AFP siRNA (h2) - sc-270319 from Santa Cruz Biotechnology
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AFP shRNA Plasmid (h2) - sc-270319-SH from Santa Cruz Biotechnology
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AFP shRNA (h2) Lentiviral Particles - sc-270319-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU046191 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2923 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2923 from Sigma-Aldrich
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AFP siRNA (Human) - CRH0123 from Cohesion Biosciences
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alpha-Fetoprotein/AFP RNAi - H00000174-R01 from Novus Biologicals
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AFP - MBS8237827 from MyBioSource
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shRNA set against Human AFP (NM_001134.1) - SHH233070 from Creative biogene
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shRNA set against Human AFP(NM_001134.1) - SHG031483 from Creative biogene
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Human AFP siRNA - orb260625 from Biorbyt
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AFP shRNA Plasmid (Human) - CHH0123 from Cohesion Biosciences
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AFP miRNA 3'UTR clone - MiUTR1H-00232 from Creative biogene
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