| Gene Symbol | MYH14 |
|---|---|
| Entrez Gene | 79784 |
| Alt Symbol | DFNA4, DFNA4A, FP17425, MHC16, MYH17, NMHC II-C, NMHC-II-C, PNMHH, myosin |
| Species | Human |
| Gene Type | protein-coding |
| Description | myosin, heavy chain 14, non-muscle |
| Other Description | MYH14 variant protein|myosin heavy chain, non-muscle IIc|myosin, heavy polypeptide 14|myosin-14|non-muscle myosin heavy chain IIc|nonmuscle myosin heavy chain II-C |
| Swissprots | Q6XYE4 B0I1S2 Q5CZ75 Q7Z406 Q96I22 Q76B62 Q9BW35 Q9H882 Q9BT27 C3TTN4 Q8WV23 |
| Accessions | EAW71838 EAW71839 EAW71840 EAW71841 EAW71842 EAW71843 Q7Z406 AB111886 BAC98374 AB290169 BAG06723 AK023943 BAB14735 AK091982 AK122704 BAG53677 AK125082 BAG54136 AK303704 BAG64689 AK307783 AV661825 AY165122 AAO39147 AY203926 AAP34449 BC000676 AAH00676 BC004396 AAH04396 BC007877 AAH07877 BC018933 AAH18933 BC129803 AAI29804 CR936653 CAI56791 DB110776 FJ041910 ACM78630 L29142 AAA20905 XM_006723386 XP_006723449 XM_011527320 XP_011525622 XM_011527321 XP_011525623 XM_011527322 XP_011525624 XM_011527323 XP_011525625 NM_001077186 NP_001070654 NM_001145809 NP_001139281 NM_024729 NP_079005 |
| Function | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. {ECO:0000250}. |
| Tissue Specificity | High levels of expression are found in brain (highest in corpus callosum), heart, kidney, liver, lung, small intestine, colon and skeletal muscle. Expression is low in organs composed mainly of smooth muscle, such as aorta, uterus and urinary bladder. No detectable expression is found in thymus, spleen, placenta and lymphocytes. {ECO:0000269|PubMed:12909352, ECO:0000269|PubMed:14594953, ECO:0000269|PubMed:19240025}. |
| Top Pathways | Tight junction, Salmonella infection, Regulation of actin cytoskeleton |
MYH14 CRISPR/Cas9 KO Plasmid (h) - sc-410131 from Santa Cruz Biotechnology
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MYH14 HDR Plasmid (h) - sc-410131-HDR from Santa Cruz Biotechnology
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MYH14 Double Nickase Plasmid (h) - sc-410131-NIC from Santa Cruz Biotechnology
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MYH14 Double Nickase Plasmid (h2) - sc-410131-NIC-2 from Santa Cruz Biotechnology
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MYH14 CRISPR Activation Plasmid (h) - sc-410131-ACT from Santa Cruz Biotechnology
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MYH14 CRISPR Activation Plasmid (h2) - sc-410131-ACT-2 from Santa Cruz Biotechnology
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MYH14 Lentiviral Activation Particles (h) - sc-410131-LAC from Santa Cruz Biotechnology
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MYH14 Lentiviral Activation Particles (h2) - sc-410131-LAC-2 from Santa Cruz Biotechnology
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MYH14 siRNA (h) - sc-97260 from Santa Cruz Biotechnology
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MYH14 shRNA Plasmid (h) - sc-97260-SH from Santa Cruz Biotechnology
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MYH14 shRNA (h) Lentiviral Particles - sc-97260-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU151361 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14816 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14816 from Sigma-Aldrich
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MYH14 siRNA (Human) - CRJ2561 from Cohesion Biosciences
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shRNA set against Human MYH14(NM_001077186.1) - SHH211295 from Creative biogene
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shRNA set against Human MYH14(NM_024729.3) - SHH211313 from Creative biogene
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MYH14 shRNA Plasmid (Human) - CHJ2561 from Cohesion Biosciences
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MYH14 miRNA 3'UTR clone - MiUTR1H-06569 from Creative biogene
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MYH14 miRNA 3'UTR clone - MiUTR1H-06570 from Creative biogene
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MYH14 miRNA 3'UTR clone - MiUTR3H-10097 from Creative biogene
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