| Gene Symbol |
FN1
|
| Entrez Gene |
2335
|
| Alt Symbol |
CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
fibronectin 1
|
| Other Description |
cold-insoluble globulin|fibronectin|migration-stimulating factor
|
| Swissprots |
Q86T27 Q6MZU5 Q68DT4 Q8IVI8 Q6MZS0 Q6LDP6 Q9H1B8 Q7Z391 Q68DP9 Q585T2 B7ZLF0 O95610 O95609 Q96KP7 Q9HAP3 Q6N0A6 Q14312 Q14325 Q68DP8 Q96KP9 Q96KP8 Q14326 E9PE77 Q59EH1 Q60FE4 Q9UMK2 Q17RV7 P02751 Q564H7 Q6N025 E9PG29
|
| Accessions |
AAA52461 AAA53376 AAA58483 AAX76513 AAY24063 CAB52436 CAB52437 EAW70530 EAW70531 EAW70532 EAW70533 EAW70534 EAW70535 EAW70536 EAW70537 EAW70538 EAW70539 EAW70540 EAW70541 EAW70542 EAW70543 EAW70544 EAW70545 EAW70546 EAW70547 EAW70548 P02751 AB191261 BAD52437 AB209287 BAD92524 AB209840 BAD93077 AF130095 AAG35520 AF312399 AAG30571 AI033037 AJ276395 CAC20427 AJ320525 CAC86914 AJ320526 CAC86915 AJ320527 CAC86916 AJ535086 CAD59389 AJ849445 CAH60958 AK026737 AK094153 AK297733 BAG60083 AK300216 BAG61984 AK300246 BAG62013 AK300458 BAG62178 AK316350 BAH14721 AL832202 CAD91166 AL832771 BC005858 AAH05858 BC016875 AAH16875 BC078656 BC100030 BC117176 AAI17177 BC143754 AAI43755 BC143763 AAI43764 BQ005645 BT006856 AAP35502 BX537590 CAD97791 BX538017 CAD97964 BX538018 CAD97965 BX538045 CAD97984 BX640608 CAE45714 BX640638 CAE45786 BX640731 CAE45847 BX640802 CAE45885 BX640803 BX640875 CAE45932 BX640920 CAE45958 BX640999 CAE46002 BX641150 BX649182 CAE46200 CA422234 CR749281 CAH18136 CR749316 CAH18171 CR749317 CAH18172 CR749666 CAH18457 CR936623 CAI56766 DA851446 EF550130 ABR68534 EF550131 ABR68535 EF550132 ABR68536 EF550133 ABR68537 EF550134 ABR68538 EF550135 ABR68539 EU831936 ACE87377 EU832031 ACE86693 M10905 AAA52462 M14059 AAA52463 M14060 AAA52464 M27589 AAA52465 M27590 AAA52466 U41724 AAD00013 U41850 AAD00014 U42404 AAD00015 U42455 AAD09448 U42456 AAD09449 U42457 AAD04751 U42458 AAD09450 U42592 AAD00017 U42593 AAD00018 U42594 AAD00019 U60067 AAD11500 U60068 AAD10853 X02761 CAA26536 XM_005246397 XP_005246454 XM_005246398 XP_005246455 XM_005246399 XP_005246456 XM_005246400 XP_005246457 XM_005246401 XP_005246458 XM_005246402 XP_005246459 XM_005246403 XP_005246460 XM_005246404 XP_005246461 XM_005246405 XP_005246462 XM_005246406 XP_005246463 XM_005246407 XP_005246464 XM_005246408 XP_005246465 XM_005246409 XP_005246466 XM_005246410 XP_005246467 XM_005246411 XP_005246468 XM_005246412 XP_005246469 XM_005246413 XP_005246470 XM_005246414 XP_005246471 XM_005246415 XP_005246472 XM_005246416 XP_005246473 XM_005246417 XP_005246474 NM_001306129 NP_001293058 NM_001306130 NP_001293059 NM_001306131 NP_001293060 NM_001306132 NP_001293061 NM_002026 NP_002017 NM_054034 NP_473375 NM_212474 NP_997639 NM_212476 NP_997641 NM_212478 NP_997643 NM_212482 NP_997647 NM_212475
|
| Function |
Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts.
|
| Subcellular Location |
Secreted, extracellular space, extracellular matrix.
|
| Tissue Specificity |
Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. Ugl-Y1, Ugl-Y2 and Ugl-Y3 are found in urine. {ECO:0000269|PubMed:17614963, ECO:0000269|PubMed:3584091}.
|
| Top Pathways |
Proteoglycans in cancer, Focal adhesion, PI3K-Akt signaling pathway, Amoebiasis, Bacterial invasion of epithelial cells
|
![Western Blot: Fibronectin Overexpression Lysate (Adult Normal) [NBP2-04486] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Fibronectin.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3973_Fibronectin%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-04486-img0001.jpg)