EPAS1

Gene Symbol	EPAS1
Entrez Gene	2034
Alt Symbol	ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73
Species	Human
Gene Type	protein-coding
Description	endothelial PAS domain protein 1
Other Description	EPAS-1|HIF-1-alpha-like factor|HIF-1alpha-like factor|HIF-2-alpha|HIF2-alpha|PAS domain-containing protein 2|basic-helix-loop-helix-PAS protein MOP2|class E basic helix-loop-helix protein 73|endothelial PAS domain-containing protein 1|hypoxia-inducible factor 2 alpha|hypoxia-inducible factor 2-alpha|member of PAS protein 2
Swissprots	Q99630 Q86VA2 Q99814
Accessions	AAX93237 AAY14704 EAX00255 Q99814 AF052094 AK123845 BAG53969 BC015869 BC051338 AAH51338 BM671511 CD109908 U51626 AAC51212 U81984 AAB41495 XM_011532698 XP_011531000 NM_001430 NP_001421
Function	Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.
Subcellular Location	Nucleus {ECO:0000250|UniProtKB:P97481, ECO:0000255|PROSITE-ProRule:PRU00981}. Nucleus speckle {ECO:0000250|UniProtKB:P97481}. Note=Colocalizes with HIF3A in the nucleus and speckles. {ECO:0000250|UniProtKB:P97481}.
Tissue Specificity	Expressed in most tissues, with highest levels in placenta, lung and heart. Selectively expressed in endothelial cells.
Top Pathways	Renal cell carcinoma

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

EPAS-1 CRISPR/Cas9 KO Plasmid (h) - sc-400647 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

EPAS-1 HDR Plasmid (h) - sc-400647-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

EPAS-1 Double Nickase Plasmid (h) - sc-400647-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

EPAS-1 Double Nickase Plasmid (h2) - sc-400647-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

EPAS-1 CRISPR Activation Plasmid (h) - sc-400647-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

EPAS-1 CRISPR Activation Plasmid (h2) - sc-400647-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

EPAS-1 Lentiviral Activation Particles (h) - sc-400647-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

EPAS-1 Lentiviral Activation Particles (h2) - sc-400647-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

EPAS-1 siRNA (h) - sc-35316 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

EPAS-1 shRNA Plasmid (h) - sc-35316-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

EPAS-1 shRNA (h) Lentiviral Particles - sc-35316-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

HIF-2 alpha/EPAS1 RNAi - H00002034-R01 from Novus Biologicals Category siRNA Prices $349.00, $399.00 Sizes 10 nmol, 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU008751 from Sigma-Aldrich Category siRNA

CompoZr® Knockout ZFN Kit - CKOZFN1246 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit - CKOZFN1018 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1246 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1018 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR12854 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr12854

EPAS1 siRNA (Human) - CRH1411 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

EPAS1 - MBS8200624 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human EPAS1 (NM_001430.4) - SHH286169 from Creative biogene Category siRNA Species Reactivities Human

Human EPAS1 siRNA - orb261913 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

EPAS1 shRNA Plasmid (Human) - CHH1411 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

EPAS1 miRNA 3'UTR clone - MiUTR4H-TG03101 from Creative biogene Species Reactivities Human

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