Gene Symbol | NBEA |
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Entrez Gene | 26960 |
Alt Symbol | BCL8B, LYST2 |
Species | Human |
Gene Type | protein-coding |
Description | neurobeachin |
Other Description | lysosomal-trafficking regulator 2 |
Swissprots | Q9HCM8 Q5T320 Q8NFP9 Q9NW98 B7Z2H9 Q9NSU1 Q9Y6J1 |
Accessions | EAX08541 EAX08542 EAX08543 EAX08544 EAX08545 Q8NFP9 AB046764 BAB13370 AF072371 AAD41633 AF467288 AAM53531 AK001059 BAA91485 AK091469 BAG52368 AK122888 BAG53781 AK127791 BAG54570 AK294737 BAH11865 AK297773 BAH12663 AK315939 BAH14310 AL137748 CAB70903 BC172597 AAI72597 BU736721 BX640760 CAE45866 DA248291 XM_005266346 XP_005266403 XM_005266347 XP_005266404 XM_005266348 XP_005266405 XM_005266350 XP_005266407 XM_006719803 XP_006719866 XM_006719805 XP_006719868 XM_006719806 XP_006719869 XM_011535045 XP_011533347 XM_011535046 XP_011533348 XM_011535047 XP_011533349 NM_001204197 NP_001191126 NM_015678 NP_056493 |
Function | Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. |
Tissue Specificity | Predominant in many brain structures. Also expressed at medium levels in spleen, thymus, prostate, testis and ovary. Low level expression is seen in heart, kidney, pancreas, skeletal muscle and intestine. {ECO:0000269|PubMed:12160729}. |
Neurobeachin CRISPR/Cas9 KO Plasmid (h) - sc-407784 from Santa Cruz Biotechnology
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Neurobeachin HDR Plasmid (h) - sc-407784-HDR from Santa Cruz Biotechnology
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Neurobeachin Double Nickase Plasmid (h) - sc-407784-NIC from Santa Cruz Biotechnology
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Neurobeachin Double Nickase Plasmid (h2) - sc-407784-NIC-2 from Santa Cruz Biotechnology
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Neurobeachin CRISPR Activation Plasmid (h) - sc-407784-ACT from Santa Cruz Biotechnology
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Neurobeachin CRISPR Activation Plasmid (h2) - sc-407784-ACT-2 from Santa Cruz Biotechnology
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Neurobeachin Lentiviral Activation Particles (h) - sc-407784-LAC from Santa Cruz Biotechnology
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Neurobeachin Lentiviral Activation Particles (h2) - sc-407784-LAC-2 from Santa Cruz Biotechnology
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Neurobeachin siRNA (h) - sc-75907 from Santa Cruz Biotechnology
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Neurobeachin shRNA Plasmid (h) - sc-75907-SH from Santa Cruz Biotechnology
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Neurobeachin shRNA (h) Lentiviral Particles - sc-75907-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU060421 from Sigma-Aldrich
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MISSION® esiRNA - EHU075581 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14978 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14978 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10290 from Sigma-Aldrich
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NBEA siRNA (Human) - CRH8905 from Cohesion Biosciences
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shRNA set against Human NBEA (NM_015678.4) - SHH349604 from Creative biogene
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Human NBEA siRNA - orb269407 from Biorbyt
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NBEA shRNA Plasmid (Human) - CHH8905 from Cohesion Biosciences
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NBEA miRNA 3'UTR clone - MiUTR3H-07174 from Creative biogene
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