| Gene Symbol |
Ube2d3
|
| Entrez Gene |
66105
|
| Alt Symbol |
1100001F19Rik, 9430029A22Rik, AA414951
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin-conjugating enzyme E2D 3
|
| Other Description |
E2(17)KB 3|ubiquitin carrier protein D3|ubiquitin-conjugating enzyme E2 D3|ubiquitin-conjugating enzyme E2(17)KB 3|ubiquitin-conjugating enzyme E2-17 kDa 3|ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)|ubiquitin-protein ligase D3
|
| Swissprots |
P61079
|
| Accessions |
EDL12149 EDL12150 EDL12151 EDL12152 EDL12153 P61079 AK003163 BAB22614 AK004001 BAB23116 AK009276 BAB26188 AK009936 AK014344 AK020443 AK032885 BAC28070 AK049906 BAC33981 AK077666 BAC36940 AK088448 BAC40357 AK090099 AK151295 BAE30279 AK151594 BAE30534 AK152231 BAE31058 AK152541 BAE31296 AK153100 BAE31721 AK153111 BAE31728 AK153410 BAE31970 AK153423 AK159125 BAE34839 AK159546 BAE35172 AK159963 BAE35518 AK165235 BAE38093 AK167077 BAE39237 AK167138 BAE39283 AK167650 BAE39701 AK167801 BAE39829 AK169177 BAE40955 AK181617 AK206793 AK208479 BC023266 BC024351 AAH24351 BC057941 AAH57941 BC098220 AAH98220 XM_006501873 XP_006501936 XM_006501874 XP_006501937 XM_006501875 XP_006501938 XM_006501876 XP_006501939 NM_025356 NP_079632
|
| Function |
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA- linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
|
| Top Pathways |
Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum
|