| Gene Symbol | Clec4e |
|---|---|
| Entrez Gene | 56619 |
| Alt Symbol | C86253, Clecsf9, Mincle |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | C-type lectin domain family 4, member e |
| Other Description | C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 9|C-type lectin domain family 4 member E|C-type lectin superfamily member 9|C-type lectin, superfamily member 9|macrophage-inducible C-type lectin |
| Swissprots | Q9R0Q8 |
| Accessions | BAA83756 EDK99715 EDK99716 EDK99717 Q9R0Q8 AB024717 BAA83754 AK036493 AK089286 AK150528 BAE29637 AK150899 BAE29944 AK151101 BAE30111 AK151912 BAE30792 AK152333 AK153008 BAE31647 AK153308 BAE31889 AK155452 BAE33271 AK156437 BAE33711 AK170698 BAE41962 AK171103 BAE42251 BC003218 AAH03218 CT010223 CAJ18431 XM_011241415 XP_011239717 NM_019948 NP_064332 |
| Function | C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B. {ECO:0000269|PubMed:10528209, ECO:0000269|PubMed:18509109, ECO:0000269|PubMed:19171887}. |
| Subcellular Location | Membrane {ECO:0000305|PubMed:10528209}; Single-pass type II membrane protein {ECO:0000305|PubMed:10528209}. |
| Tissue Specificity | Expressions were observed in peritoneal macrophage, macrophage cell line RAW 264.7, and myeloblastic leukemia cell line M1 following inflammatory stimuli. {ECO:0000269|PubMed:10528209}. |
| Top Pathways | Tuberculosis |
CLEC-4E CRISPR/Cas9 KO Plasmid (m) - sc-425240 from Santa Cruz Biotechnology
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CLEC-4E HDR Plasmid (m) - sc-425240-HDR from Santa Cruz Biotechnology
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CLEC-4E Double Nickase Plasmid (m) - sc-425240-NIC from Santa Cruz Biotechnology
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CLEC-4E Double Nickase Plasmid (m2) - sc-425240-NIC-2 from Santa Cruz Biotechnology
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CLEC-4E CRISPR Activation Plasmid (m) - sc-425240-ACT from Santa Cruz Biotechnology
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CLEC-4E CRISPR Activation Plasmid (m2) - sc-425240-ACT-2 from Santa Cruz Biotechnology
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CLEC-4E Lentiviral Activation Particles (m) - sc-425240-LAC from Santa Cruz Biotechnology
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CLEC-4E Lentiviral Activation Particles (m2) - sc-425240-LAC-2 from Santa Cruz Biotechnology
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CLEC-4E siRNA (m) - sc-142388 from Santa Cruz Biotechnology
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CLEC-4E shRNA Plasmid (m) - sc-142388-SH from Santa Cruz Biotechnology
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CLEC-4E shRNA (m) Lentiviral Particles - sc-142388-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU044811 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN28869 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND28869 from Sigma-Aldrich
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CLEC4E siRNA (Mouse) - CRM5871 from Cohesion Biosciences
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CLEC4E - MBS8200933 from MyBioSource
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shRNA set against Mouse CLEC4E (NM_019948.2) - SHH265173 from Creative biogene
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shRNA set against Mouse Clec4e(NM_019948.2) - SHG181981 from Creative biogene
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Mouse CLEC4E siRNA - orb285347 from Biorbyt
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CLEC4E shRNA Plasmid (Mouse) - CHM5871 from Cohesion Biosciences
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CLEC4E miRNA 3'UTR clone - MiUTR1M-03084 from Creative biogene
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