Gene Symbol | ACAD8 |
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Entrez Gene | 27034 |
Alt Symbol | ACAD-8, ARC42 |
Species | Human |
Gene Type | protein-coding |
Description | acyl-CoA dehydrogenase family, member 8 |
Other Description | activator-recruited cofactor 42 kDa component|acyl-Coenzyme A dehydrogenase family, member 8|isobutyryl-CoA dehydrogenase, mitochondrial |
Swissprots | Q6ZWP6 Q9UKU7 Q9BUS8 B7Z5W4 |
Accessions | AAF97922 CAF85883 EAW67833 EAW67834 EAW67835 Q9UKU7 AB209538 BAD92775 AF126245 AAF12736 AK000359 BAA91109 AK026243 AK074640 BAC11107 AK124235 AK125373 BAC86149 AK299492 BAH13050 AK299795 BAH13130 AK301518 BAH13503 AK301921 BAH13587 AK303569 BAH13987 AK309051 AK309838 AK315980 BAH14351 BC001964 AAH01964 BI549961 DQ891093 ABM82019 DQ894275 ABM85201 XM_005271501 XP_005271558 XM_005271505 XP_005271562 XM_011542750 XP_011541052 XR_947819 XR_947820 XR_947821 XR_947822 XR_947823 NM_014384 NP_055199 |
Function | Has very high activity toward isobutyryl-CoA. Is an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Plays a role in transcriptional coactivation within the ARC complex. {ECO:0000269|PubMed:12359132}. |
Subcellular Location | Mitochondrion {ECO:0000269|PubMed:11013134}. |
Tissue Specificity | Detected at comparable levels in all tissues examined (heart, lung, brain, skeletal muscle, pancreas and placenta). Weakly expressed in liver and kidney. |
Top Pathways | Valine, leucine and isoleucine degradation |
ACAD-8 CRISPR/Cas9 KO Plasmid (h) - sc-411948 from Santa Cruz Biotechnology
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ACAD-8 HDR Plasmid (h) - sc-411948-HDR from Santa Cruz Biotechnology
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ACAD-8 Double Nickase Plasmid (h) - sc-411948-NIC from Santa Cruz Biotechnology
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ACAD-8 Double Nickase Plasmid (h2) - sc-411948-NIC-2 from Santa Cruz Biotechnology
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ACAD-8 CRISPR Activation Plasmid (h) - sc-411948-ACT from Santa Cruz Biotechnology
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ACAD-8 CRISPR Activation Plasmid (h2) - sc-411948-ACT-2 from Santa Cruz Biotechnology
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ACAD-8 Lentiviral Activation Particles (h) - sc-411948-LAC from Santa Cruz Biotechnology
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ACAD-8 Lentiviral Activation Particles (h2) - sc-411948-LAC-2 from Santa Cruz Biotechnology
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ACAD-8 siRNA (h) - sc-61932 from Santa Cruz Biotechnology
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ACAD-8-shRNA Plasmid (h) - sc-61932-SH from Santa Cruz Biotechnology
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ACAD-8-shRNA (h) Lentiviral Particles - sc-61932-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU052471 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2689 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2689 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07504 from Sigma-Aldrich
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ACAD8 siRNA (Human) - CRH8932 from Cohesion Biosciences
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ACAD8 RNAi - H00027034-R01 from Novus Biologicals
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ACAD8 - MBS8217381 from MyBioSource
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shRNA set against Human ACAD8 (NM_014384.2) - SHH229894 from Creative biogene
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shRNA set against Human ACAD8(NM_014384.2) - SHG027883 from Creative biogene
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ACAD8 shRNA Plasmid (Human) - CHH8932 from Cohesion Biosciences
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ACAD8 miRNA 3'UTR clone - MiUTR1H-00090 from Creative biogene
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