AP2A2

Gene Symbol AP2A2
Entrez Gene 161
Alt Symbol ADTAB, CLAPA2, HIP-9, HIP9, HYPJ
Species Human
Gene Type protein-coding
Description adaptor-related protein complex 2, alpha 2 subunit
Other Description 100 kDa coated vesicle protein C|AP-2 complex subunit alpha-2|adapter-related protein complex 2 subunit alpha-2|adaptin, alpha B|adaptor-related protein complex 2 subunit alpha-2|alpha-adaptin C; Huntingtin interacting protein J|alpha2-adaptin|clathrin assembly protein complex 2 alpha-C large chain|clathrin-associated/assembly/adaptor protein, large, alpha 2|huntingtin yeast partner J|huntingtin-interacting protein 9|plasma membrane adaptor HA2/AP2 adaptin alpha C subunit
Swissprots O75403 Q96SI8 O94973 Q53ET1
Accessions EAX02416 EAX02417 EAX02418 EAX02419 O94973 AB020706 BAA74922 AB209422 BAD92659 AF049527 AAC27505 AK001986 BAG50999 AK027640 AK027891 BAB55435 AK075497 BAC11653 AK094496 AK095725 AK223558 BAD97278 AK293763 BAH11590 AK299364 BAH13015 AL117614 CAB56015 BC006155 AAH06155 BG705558 BI462785 BU735076 DB461570 DQ893441 ABM84367 DQ896779 ABM87778 XM_011519928 XP_011518230 XM_011519929 XP_011518231 XM_011519930 XP_011518232 XR_930847 NM_001242837 NP_001229766 NM_012305 NP_036437
Function Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to p
Subcellular Location Cell membrane {ECO:0000250}. Membrane, coated pit {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV. {ECO:0000250}.
Top Pathways Huntington's disease, Endocytosis, Endocrine and other factor-regulated calcium reabsorption, Synaptic vesicle cycle

α-Adaptin 1/2 (C-8) - sc-17771 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
α-Adaptin 1/2 (C-8): sc-17771. Immunoperoxidase staining of formalin fixed, paraffin-embedded human cervix, uterine tissue showing membrane staining of glandular cells and squamous epithelial cells. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

α-Adaptin 1/2 (M-300) - sc-10761 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
α-Adaptin 1/2 (M-300): sc-10761. Western blot analysis of α-Adaptin 1/2 expression in KNRK (A) and Hep G2 (B) whole cell lysates.

α-Adaptin 2 (F-12) - sc-55497 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
α-Adaptin (F-12): sc-55497. Western blot analysis of α-Adaptin expression in Hep G2 (A) and NIH/3T3 (B) whole cell lysates and mouse liver tissue extract (C).

α-Adaptin 2 (M-16) - sc-6422 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
α-Adaptin (C) (M-16): sc-6422. Immunofluorescence staining of methanol-fixed KNRK cells showing cytoplasmic localization.

Anti-AP2A2 Antibody (Internal, Biotin) - LS-C275158 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AP2A2 Antibody (Internal, APC) - LS-C275159 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AP2A2 Antibody (Internal, Azide-free, HRP) - LS-C275161 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AP2A2 Antibody (Internal, PE) - LS-C275162 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AP2A2 Antibody (Internal, FITC) - LS-C275160 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AP2A2 Antibody (Internal, AP) - LS-C275155 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AP2A2 Antibody (Internal) - LS-C326853 from LifeSpan Bioscience

Prices $425.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AP2A2 Antibody - LS-C341605 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-AP2A2 Antibody (aa612-661) - LS-C135682 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
AP2A2 antibody LS-C135682 Western blot of Fetal Lung lysate.

Anti-AP2A2 Antibody - LS-C334033 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded human kidney using AP2A2 antibody at dilution of 1:200 (x400 lens)

Anti-AP2A2 Antibody (aa610-637) - LS-C156387 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human hepatocarcinoma with AP2A2 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

AP2A2 Antibody - NBP1-68948 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: AP2A2 Antibody [NBP1-68948] - Human Lung lysate, concentration 0.2-1 ug/ml.

AP2A2 Antibody - NBP2-29928 from Novus Biologicals

Prices $329.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western Blot: AP2A2 Antibody [NBP2-29928] - Western blot analysis of AP2A2 Antibody (Center) (NBP2-29928) in HepG2 cell line lysates (35ug/lane). AP2A2 (arrow) was detected using the purified Pab.

AP2A2 Antibody - NBP2-15417 from Novus Biologicals

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: AP2A2 Antibody [NBP2-15417] - Sample (50 ug of whole cell lysate) A: Mouse brain 5% SDS PAGE, antibody diluted at 1:500.

Anti-AP2A2 antibody produced in rabbit - SAB2701137 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-AP2A2: <B>Cat. No. SAB2701137</B>: Western Blot analysis of AP2A2 in extracts from <B>Lanes</B><BR/>A. Mouse brain using <B>Cat. No. SAB2701137</B> at a 1:500 dilution.

Anti-AP2A2 (631-643) antibody produced in rabbit - A9858 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-AP2A2 (631-643): <B>Cat. No. A9858</B>: Immunofluorescence of HUVEC cells using AP2A2 (631-643) (RB),<B>Cat. No. A9858</B> (red) at a 1:100 dilution, taken at 40× magnification and nuclear staining with Hoescht 33342 (blue).Yale HTCB IF procedure used. Images have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

Anti-AP2A2 (761-773) antibody produced in rabbit - A9983 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-AP2A2 (761-773): <B>Cat. No. A9983</B>: Immunofluorescence of HUVEC cells using AP2A2 (761-773) (RB),<B>Cat. No. A9983</B> (red) at a 1:200 dilution, taken at 40× magnification and nuclear staining with Hoescht 33342 (blue).Yale HTCB IF procedure used. Images have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

AP2A2 Antibody (OAAD00215) - OAAD00215 from Aviva Systems Biology

Prices $255.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone Ada-1

AP2A2 antibody - C-terminal region (ARP59974_P050) - ARP59974_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

AP2A2-Antibody-Center - AP8551c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human hepatocarcinoma with AP2A2 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

AP2A2 Antibody - middle region (OAAB05143) - OAAB05143 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
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