| Gene Symbol | Vps36 |
|---|---|
| Entrez Gene | 70160 |
| Alt Symbol | 1700010A24Rik, 2210415M20Rik, 2810408E15Rik, Eap45 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | vacuolar protein sorting 36 (yeast) |
| Other Description | ESCRT-II complex subunit VPS36|vacuolar protein-sorting-associated protein 36 |
| Swissprots | Q91XD6 Q9CVA3 |
| Accessions | EDL32902 Q91XD6 AK005810 AK008946 BAB25984 AK013045 AK150754 BAE29824 AK151035 BAE30052 AK156241 AK161865 BAE36614 AK211474 BC010811 AAH10811 NM_027338 NP_081614 |
| Function | Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3 (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Endosome {ECO:0000250}. Late endosome {ECO:0000250}. Membrane {ECO:0000250}. Nucleus {ECO:0000250}. Note=Colocalizes with ubiquitinated proteins on late endosomes. Recruited to the endosome membrane to participate in vesicle formation. {ECO:0000250}. |
| Top Pathways | Endocytosis |