| Gene Symbol |
MAP1LC3B2
|
| Entrez Gene |
643246
|
| Alt Symbol |
ATG8G
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
microtubule-associated protein 1 light chain 3 beta 2
|
| Other Description |
Microtubule-associated proteins 1A/1B light chain 3B-like protein|microtubule-associated proteins 1A/1B light chain 3 beta 2
|
| Swissprots |
A6NCE7
|
| Accessions |
A6NCE7 EAW98085 BC156862 AAI56863 XM_011538652 XP_011536954 NM_001085481 NP_001078950
|
| Function |
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton {ECO:0000250}. Endomembrane system {ECO:0000250}; Lipid-anchor {ECO:0000250}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250}; Lipid- anchor {ECO:0000250}. Note=LC3-II binds to the autophagic membranes. {ECO:0000250}.
|