| Gene Symbol |
PTPRK
|
| Entrez Gene |
5796
|
| Alt Symbol |
R-PTP-kappa
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein tyrosine phosphatase, receptor type, K
|
| Other Description |
dJ480J14.2.1 (protein tyrosine phosphatase, receptor type, K (R-PTP-KAPPA, protein tyrosine phosphatase kappa , protein tyrosine phosphatase kappa|protein-tyrosine phosphatase kappa|protein-tyrosine phosphatase, receptor type, kappa|receptor-type tyrosine-protein phosphatase kappa
|
| Swissprots |
B7ZMG0 Q5TG10 Q15262 Q14763 Q5TG11 B2RTQ8
|
| Accessions |
CCF77037 CCF77038 EAW48084 EAW48085 EAW48086 EAW48087 EAW48088 EAW48089 Q15262 AB209670 BAD92907 AF533875 AAO49502 AK295028 BAG58084 BC063596 AAH63596 BC140775 AAI40776 BC144512 AAI44513 BC144513 AAI44514 BI755683 BQ018138 BX647498 CR749277 CAH18132 DA790525 DB020920 EF139847 L77886 AAC37599 Z70660 CAA94519 XM_006715537 XP_006715600 XM_006725019 XP_006725082 XM_011536014 XP_011534316 XM_011536015 XP_011534317 XM_011536016 XP_011534318 XM_011536017 XP_011534319 XM_011536018 XP_011534320 XM_011536019 XP_011534321 XM_011536020 XP_011534322 XM_011536021 XP_011534323 XM_011546488 XP_011544790 XM_011546489 XP_011544791 XM_011546490 XP_011544792 XM_011546491 XP_011544793 XM_011546492 XP_011544794 XM_011546493 XP_011544795 XM_011546494 XP_011544796 XM_011546495 XP_011544797 NM_001135648 NP_001129120 NM_001291981 NP_001278910 NM_001291982 NP_001278911 NM_001291983 NP_001278912 NM_001291984 NP_001278913 NM_002844 NP_002835
|
| Function |
Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa. {ECO:0000269|PubMed:19836242}.
|
| Subcellular Location |
Cell junction, adherens junction. Cell membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
High levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma.
|