| Gene Symbol | PER3 |
|---|---|
| Entrez Gene | 8863 |
| Alt Symbol | GIG13 |
| Species | Human |
| Gene Type | protein-coding |
| Description | period circadian clock 3 |
| Other Description | cell growth-inhibiting gene 13 protein|circadian clock protein PERIOD 3|growth-inhibiting protein 13|hPER3|period 3|period circadian protein 3|period circadian protein homolog 3|period homolog 3 |
| Swissprots | Q969K6 Q9UGU8 Q9NSP9 Q9C0J3 Q96S77 Q5H8X5 Q96S78 P56645 Q5H8X4 |
| Accessions | ABM64204 BAB63250 BAB63251 BAB63252 BAB63253 BAB63254 BAB63255 EAW71583 EAW71584 EAW71585 EAW71586 P56645 AB047686 BAB32925 AK299123 BAG61177 AK307760 AK308303 AL157954 CAB76084 AY493418 AAS72879 BC026102 AAH26102 BC111010 AAI11011 BC144137 BC146781 AAI46782 CN480408 HY151851 JF432535 ADZ15752 XM_005263521 XP_005263578 XM_005263522 XP_005263579 XM_005263523 XP_005263580 XM_005263524 XP_005263581 XM_005263529 XP_005263586 XM_011542384 XP_011540686 XM_011542385 XP_011540687 XM_011542386 XP_011540688 XM_011542387 XP_011540689 XM_011542388 XP_011540690 XM_011542389 XP_011540691 XM_011542390 XP_011540692 NM_001289861 NP_001276790 NM_001289862 NP_001276791 NM_001289863 NP_001276792 NM_001289864 NP_001276793 NM_016831 NP_058515 |
| Function | Originally described as a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directl |
| Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Mainly cytoplasmic. Translocates to the nucleus through binding PER1, PER2, CRY1 or CRY2, but not TIMELESS (By similarity). {ECO:0000250}. |
| Top Pathways | Circadian rhythm, Herpes simplex infection, Circadian entrainment |
Per3 CRISPR/Cas9 KO Plasmid (h) - sc-411220 from Santa Cruz Biotechnology
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Per3 HDR Plasmid (h) - sc-411220-HDR from Santa Cruz Biotechnology
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Per3 Double Nickase Plasmid (h) - sc-411220-NIC from Santa Cruz Biotechnology
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Per3 Double Nickase Plasmid (h2) - sc-411220-NIC-2 from Santa Cruz Biotechnology
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Per3 CRISPR Activation Plasmid (h) - sc-411220-ACT from Santa Cruz Biotechnology
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Per3 CRISPR Activation Plasmid (h2) - sc-411220-ACT-2 from Santa Cruz Biotechnology
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Per3 Lentiviral Activation Particles (h) - sc-411220-LAC from Santa Cruz Biotechnology
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Per3 Lentiviral Activation Particles (h2) - sc-411220-LAC-2 from Santa Cruz Biotechnology
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Per3 siRNA (h) - sc-38173 from Santa Cruz Biotechnology
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Per3 shRNA Plasmid (h) - sc-38173-SH from Santa Cruz Biotechnology
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Per3 shRNA (h) Lentiviral Particles - sc-38173-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU081231 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16623 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16623 from Sigma-Aldrich
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PER3 siRNA (Human) - CRH5854 from Cohesion Biosciences
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shRNA set against Human PER3 (NM_016831.1) - SHH373560 from Creative biogene
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shRNA set against Human PER3(NM_016831.1) - SHR095280 from Creative biogene
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Human PER3 siRNA - orb266356 from Biorbyt
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PER3 shRNA Plasmid (Human) - CHH5854 from Cohesion Biosciences
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PER3 miRNA 3'UTR clone - MiUTR1H-07785 from Creative biogene
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