| Gene Symbol | ITGA2B |
|---|---|
| Entrez Gene | 3674 |
| Alt Symbol | BDPLT16, BDPLT2, CD41, CD41B, GP2B, GPIIb, GT, GTA, HPA3, PPP1R93 |
| Species | Human |
| Gene Type | protein-coding |
| Description | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) |
| Other Description | GPalpha IIb|integrin alpha-IIb|platelet fibrinogen receptor, alpha subunit|platelet membrane glycoprotein IIb|platelet-specific antigen BAK|protein phosphatase 1, regulatory subunit 93 |
| Swissprots | Q14443 P08514 B2RCY8 Q17R67 O95366 |
| Accessions | AAA52587 AAA52588 AAA52598 AAA52599 AAA53150 ADZ28529 ADZ28530 ADZ55421 AFN53559 EAW51594 EAW51595 EAW51596 EAW51597 P08514 AB209552 BAD92789 AF098114 AAC98507 AK297155 BAG59654 AK303081 BAH13896 AK315335 BAG37735 BC117443 AAI17444 BC126442 AAI26443 BE409167 BM148153 DQ841705 ABI15196 J02764 AAA60114 M18085 AAA52597 M34480 AAA35926 X06831 CAA29987 XM_011524749 XP_011523051 XM_011524750 XP_011523052 NM_000419 NP_000410 |
| Function | Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. |
| Subcellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U-937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells. |
| Top Pathways | Hypertrophic cardiomyopathy (HCM), Rap1 signaling pathway, PI3K-Akt signaling pathway, Dilated cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy (ARVC) |