ITGA2B

Gene Symbol	ITGA2B
Entrez Gene	3674
Alt Symbol	BDPLT16, BDPLT2, CD41, CD41B, GP2B, GPIIb, GT, GTA, HPA3, PPP1R93
Species	Human
Gene Type	protein-coding
Description	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
Other Description	GPalpha IIb|integrin alpha-IIb|platelet fibrinogen receptor, alpha subunit|platelet membrane glycoprotein IIb|platelet-specific antigen BAK|protein phosphatase 1, regulatory subunit 93
Swissprots	Q14443 P08514 B2RCY8 Q17R67 O95366
Accessions	AAA52587 AAA52588 AAA52598 AAA52599 AAA53150 ADZ28529 ADZ28530 ADZ55421 AFN53559 EAW51594 EAW51595 EAW51596 EAW51597 P08514 AB209552 BAD92789 AF098114 AAC98507 AK297155 BAG59654 AK303081 BAH13896 AK315335 BAG37735 BC117443 AAI17444 BC126442 AAI26443 BE409167 BM148153 DQ841705 ABI15196 J02764 AAA60114 M18085 AAA52597 M34480 AAA35926 X06831 CAA29987 XM_011524749 XP_011523051 XM_011524750 XP_011523052 NM_000419 NP_000410
Function	Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U-937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells.
Top Pathways	Hypertrophic cardiomyopathy (HCM), Rap1 signaling pathway, PI3K-Akt signaling pathway, Dilated cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy (ARVC)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Integrin alpha 2b + beta 3 full length protein - ab95130 from Abcam Category Protein Prices $609.00 Sizes 1 mg Source Native Species Human

Human CD41 peptide - ab95922 from Abcam Category Peptide Prices $176.00 Sizes 100 µg Species Human

ITGA2B / CD41 Antibody Blocking Peptide - LS-E23324 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Integrin alpha 2b beta 3, CF - 7148-A2-025 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived

Human CD41 protein - orb246226 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human CD41 protein - orb246754 from Biorbyt Category Protein Prices $213.00, $408.00, $680.00, $1,122.00, $1,777.00 Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg Species Human

CD41 / ITGA2B - H00003674-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CD41 / ITGA2B - H00003674-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

CD41/Integrin alpha 2b fusion protein - Ag19459 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T Species Human

CD41/Integrin alpha 2b fusion protein - Ag19469 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Platelet Membrane Glycoprotein IIB Peptide (296-306) - 88469 from NeoScientific Category Peptide Prices $90.00, $150.00, $300.00 Sizes 5 mg, 10 mg, 25 mg

Recombinant Human ITGA2B, GST-tagged - ITGA2B-174H from Creative Biomart Category Protein Source E.coli Species Human

Native Human GPIIbIIIa - ITGA2B-10H from Creative Biomart Category Protein Source Human plasma Species Human

Human GPIIbIIIa - GP2B3A from Molecular Innovations Category Protein Prices $335.00, $575.00 Sizes 1 mg, 2 mg Source Human plasma Species Human

Recombinant Integrin Alpha 2B (ITGa2B) - RPB029Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

CD41 HC Blocking Peptide - CBP3559 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

CD41 LC 1 Blocking Peptide - CBP3560 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Rat

Human GPIIbIIIa - PG52412 from AssayPro Prices $350.00 Sizes 500 µg Source Human Platelets Species Human

Recombinant Integrin Alpha 2B (ITGa2B) - RPB029Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant human Integrin alpha-IIb - CSB-EP011865HU CSB-BP011865HU CSB-MP011865HU from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human Integrin alpha-IIb(ITGA2B) ,partial - CSB-YP011865HU CSB-BP011865HU CSB-MP011865HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant Human Integrin alpha-IIb(ITGA2B) ,partial - CSB-EP011865HU from Cusabio Category Protein Source Yeast Species Human

Recombinant Human Integrin alpha 2b beta 3 Protein, CF - 7148-A2 from R&D Systems Category Protein Prices $359.00 Sizes 25 µg Source Chinese Hamster Ovary cell line, CHO-derived Human Integrin alpha 2b Met1-Arg993 (R887L) Accession # P08514 GGGSGGGSGGGS Acidic Tail HHHHHH Human Integrin beta 3 (Gly27-Asp718) Accession # AAA52589 HP GGGSGGGSGGGS Basic Tail N-terminus C-terminus Species Human

CD41 / ITGA2B - TP322614 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Platelet Membrane Glycoprotein IIB Peptide (296-306) - abx266227 from Abbexa Category Peptide

Search more