| Gene Symbol | INPPL1 |
|---|---|
| Entrez Gene | 3636 |
| Alt Symbol | OPSMD, SHIP2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | inositol polyphosphate phosphatase-like 1 |
| Other Description | 51C protein|INPPL-1|SH2 domain-containing inositol 5'-phosphatase 2|SH2 domain-containing inositol-5'-phosphatase 2|SHIP-2|phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2|phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2|protein 51C |
| Swissprots | Q13578 B2RTX5 O15357 Q13577 |
| Accessions | EAW74854 EAW74855 O15357 BC140853 AAI40854 BG236320 L24444 AAA50503 L36818 AAA96658 Y14385 CAA74743 XM_005273978 XP_005274035 XM_005273979 XP_005274036 XM_011544999 XP_011543301 XM_011545000 XP_011543302 NM_001567 NP_001558 |
| Function | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol- 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking. Confers resistance to dietary obesity. May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane. Part of a signaling pathway that regulates actin cytoskeleton remodeling. Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation. Participates in regulation of cortical and submembraneous actin by hyd |
| Subcellular Location | Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Cell projection, filopodium. Cell projection, lamellipodium. Note=Translocates to membrane ruffles when activated, translocation is probably due to different mechanisms depending on the stimulus and cell type. Partly translocated via its SH2 domain which mediates interaction with tyrosine phosphorylated receptors such as the FC-gamma-RIIB receptor (FCGR2B). Tyrosine phosphorylation may also participate in membrane localization. Insulin specifically stimulates its redistribution from the cytosol to the plasma membrane. Recruited to the membrane following M-CSF stimulation. In activated spreading platelets, localizes with actin at filopodia, lamellipodia and the central actin ring. |
| Tissue Specificity | Widely expressed, most prominently in skeletal muscle, heart and brain. Present in platelets. Expressed in transformed myeloid cells and in primary macrophages, but not in peripheral blood monocytes. {ECO:0000269|PubMed:12676785, ECO:0000269|PubMed:12690104, ECO:0000269|PubMed:8530088, ECO:0000269|PubMed:9367831, ECO:0000269|PubMed:9660833}. |
| Top Pathways | B cell receptor signaling pathway, Insulin signaling pathway, Fc gamma R-mediated phagocytosis, Inositol phosphate metabolism, Phosphatidylinositol signaling system |