INPPL1

Gene Symbol	INPPL1
Entrez Gene	3636
Alt Symbol	OPSMD, SHIP2
Species	Human
Gene Type	protein-coding
Description	inositol polyphosphate phosphatase-like 1
Other Description	51C protein|INPPL-1|SH2 domain-containing inositol 5'-phosphatase 2|SH2 domain-containing inositol-5'-phosphatase 2|SHIP-2|phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2|phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2|protein 51C
Swissprots	Q13578 B2RTX5 O15357 Q13577
Accessions	EAW74854 EAW74855 O15357 BC140853 AAI40854 BG236320 L24444 AAA50503 L36818 AAA96658 Y14385 CAA74743 XM_005273978 XP_005274035 XM_005273979 XP_005274036 XM_011544999 XP_011543301 XM_011545000 XP_011543302 NM_001567 NP_001558
Function	Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol- 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking. Confers resistance to dietary obesity. May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane. Part of a signaling pathway that regulates actin cytoskeleton remodeling. Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation. Participates in regulation of cortical and submembraneous actin by hyd
Subcellular Location	Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Cell projection, filopodium. Cell projection, lamellipodium. Note=Translocates to membrane ruffles when activated, translocation is probably due to different mechanisms depending on the stimulus and cell type. Partly translocated via its SH2 domain which mediates interaction with tyrosine phosphorylated receptors such as the FC-gamma-RIIB receptor (FCGR2B). Tyrosine phosphorylation may also participate in membrane localization. Insulin specifically stimulates its redistribution from the cytosol to the plasma membrane. Recruited to the membrane following M-CSF stimulation. In activated spreading platelets, localizes with actin at filopodia, lamellipodia and the central actin ring.
Tissue Specificity	Widely expressed, most prominently in skeletal muscle, heart and brain. Present in platelets. Expressed in transformed myeloid cells and in primary macrophages, but not in peripheral blood monocytes. {ECO:0000269|PubMed:12676785, ECO:0000269|PubMed:12690104, ECO:0000269|PubMed:8530088, ECO:0000269|PubMed:9367831, ECO:0000269|PubMed:9660833}.
Top Pathways	B cell receptor signaling pathway, Insulin signaling pathway, Fc gamma R-mediated phagocytosis, Inositol phosphate metabolism, Phosphatidylinositol signaling system

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human INPPL1 protein fragment - ab158766 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human SHIP2/INPPL1 Protein - H00003636-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SHIP2/INPPL1 Peptide - P3325 from Novus Biologicals Category Peptide Species Human

SHIP2/INPPL1 Peptide - P3324 from Novus Biologicals Category Peptide Species Human

SHIP2-Antibody-C-term-Blocking-Peptide - BP8473e from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SHIP2-Antibody-N-term-Blocking-Peptide - BP8473d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

INPPL1 - H00003636-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

INPPL1 - H00003636-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SHIP2 Blocking Peptide - CBP4033 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Pig

Recombinant Human Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2(INPP - CSB-YP521146HU CSB-EP521146HU CSB-BP521146HU CSB-MP521146HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

INPPL1 fusion protein - Ag24790 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (INPPL1), partial, Recombinant Protein - MBS1140625 from MyBioSource Category Protein Prices $835.00, $950.00, $1,055.00, $1,170.00, $1,170.00, $1,390.00, $1,620.00, $1,850.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 1 mg (E-Coli), 50 µg (Mammalian-Cell), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

SHIP2/INPPL1 Recombinant Protein Antigen - NBP1-87046PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SHIP2 Blocking Peptide - abx162526 from Abbexa Category Peptide Species Human, Mouse, Rat, Pig

SHIP2 Blocking Peptide - abx061126 from Abbexa Category Peptide Species Human, Mouse, Rat

INPPL1 Peptide, Human - M34GP07669H from Creative Peptides Category Peptide Source Synthetic. Species Human

SHIP2 Blocking Peptide - CBP5039 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

SHIP2 peptide - orb256920 from Biorbyt Category Peptide

INPPL1 peptide - orb319185 from Biorbyt Category Peptide

Search more