| Gene Symbol |
Paip1
|
| Entrez Gene |
218693
|
| Alt Symbol |
PAIP-1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
polyadenylate binding protein-interacting protein 1
|
| Other Description |
PABP-interacting protein 1|poly(A)-binding protein-interacting protein 1|polyadenylate-binding protein-interacting protein 1
|
| Swissprots |
Q8VE62 Q9WUC9
|
| Accessions |
EDL18348 Q8VE62 AF128835 AAD28259 AK040012 AK082861 AK142913 BB202059 BC019726 AAH19726 BC051042 AAH51042 CB840007 CD363907 CJ173734 XM_006517631 XP_006517694 XM_006517632 XP_006517695 XM_006517633 XP_006517696 XM_006517634 XP_006517697 XM_011244656 XP_011242958 NM_001079849 NP_001073318 NM_145457 NP_663432
|
| Function |
Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000305}.
|
| Top Pathways |
RNA transport
|