| Gene Symbol |
NAA15
|
| Entrez Gene |
80155
|
| Alt Symbol |
Ga19, NARG1, NAT1P, NATH, TBDN, TBDN100
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
|
| Other Description |
N-alpha-acetyltransferase 15, NatA auxiliary subunit|N-terminal acetyltransferase|NMDA receptor regulated 1|NMDA receptor-regulated protein 1|gastric cancer antigen Ga19|protein tubedown-1|transcriptional coactivator tubedown-100|tubedown-1
|
| Swissprots |
Q52LG9 Q9BXJ9 Q8IWH4 Q9H8P6 Q8NEV2 D3DNY6
|
| Accessions |
AAY40950 CAD28977 CAE90974 EAX05118 EAX05119 EAX05120 Q9BXJ9 AF327722 AAK15707 AJ314788 CAC43228 AK001595 AK023387 AK023402 BAB14562 AK304417 BAG65248 AK314626 BAG37192 AY039242 AAK68661 AY112670 AAM48746 BC032642 AAH32642 BC039818 AAH39818 BC093928 AAH93928 BC104806 AAI04807 XM_005263236 XP_005263293 NM_057175 NP_476516
|
| Function |
Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter. {ECO:0000269|PubMed:11687548, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:15496142}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Mainly cytoplasmic, nuclear in some cases. Present in the free cytosolic and cytoskeleton-bound polysomes, but not in the membrane-bound polysomes.
|
| Tissue Specificity |
Expressed at high levels in testis and in ocular endothelial cells. Also found in brain (corpus callosum), heart, colon, bone marrow and at lower levels in most adult tissues, including thyroid, liver, pancreas, mammary and salivary glands, lung, ovary, urogenital system and upper gastrointestinal tract. Overexpressed in gastric cancer, in papillary thyroid carcinomas and in a Burkitt lymphoma cell line (Daudi). Specifically suppressed in abnormal proliferating blood vessels in eyes of patients with proliferative diabetic retinopathy. {ECO:0000269|PubMed:11687548, ECO:0000269|PubMed:12087473, ECO:0000269|PubMed:12140756}.
|