ASMT
| Gene Symbol | ASMT |
|---|---|
| Entrez Gene | 438 |
| Alt Symbol | ASMTY, HIOMT, HIOMTY |
| Species | Human |
| Gene Type | protein-coding |
| Description | acetylserotonin O-methyltransferase |
| Other Description | acetylserotonin N-methyltransferase|acetylserotonin methyltransferase (Y chromosome)|hydroxyindole O-methyltransferase |
| Swissprots | B2RC33 Q5JQ73 Q16598 Q5JQ72 P46597 |
| Accessions | AAA75289 AAA75290 AAA75291 EAW98685 EAW98686 P46597 AK314922 BAG37430 BC001620 AAH01620 KJ534774 AHW56414 KJ534775 AHW56415 KJ534776 AHW56416 KJ535045 AHW56684 M83779 AAA17020 U11090 AAA58582 U11091 AAA58583 NM_001171038 NP_001164509 NM_001171039 NP_001164510 NM_004043 NP_004034 |
| Function | Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5- methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity. {ECO:0000269|PubMed:22775292}. |
| Tissue Specificity | Expressed in the pineal gland (at protein level). In the retina, very low expression is found at the mRNA level (PubMed:7989373), and not at the protein level (PubMed:8574683). {ECO:0000269|PubMed:22775292, ECO:0000269|PubMed:7989373, ECO:0000269|PubMed:8574683}. |
| Top Pathways | Tryptophan metabolism |
ASMT siRNA (h) - sc-91581 from Santa Cruz Biotechnology
|
||||||||
ASMT shRNA Plasmid (h) - sc-91581-SH from Santa Cruz Biotechnology
|
||||||||
ASMT shRNA (h) Lentiviral Particles - sc-91581-V from Santa Cruz Biotechnology
|
||||||||
ASMT RNAi - H00000438-R01 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU094351 from Sigma-Aldrich
|
||||||||
ASMT siRNA (Human) - CRH0315 from Cohesion Biosciences
|
||||||||
ASMT - MBS8205398 from MyBioSource
|
||||||||
shRNA set against Human ASMT (NM_004043.2) - SHH241522 from Creative biogene
|
||||||||
Human ASMT siRNA - orb260817 from Biorbyt
|
||||||||
ASMT shRNA Plasmid (Human) - CHH0315 from Cohesion Biosciences
|
||||||||
ASMT miRNA 3'UTR clone - MiUTR1H-00639 from Creative biogene
|