| Gene Symbol |
FKBP4
|
| Entrez Gene |
508535
|
| Alt Symbol |
FKBP-4, FKBP-52
|
| Species |
Bovine
|
| Gene Type |
protein-coding
|
| Description |
FK506 binding protein 4, 59kDa
|
| Other Description |
52 kDa FK506-binding protein|52 kDa FKBP|FK506-binding protein 4|FKBP52 protein|FKBP59|HBI|HSP-binding immunophilin|PPIase FKBP4|immunophilin FKBP52|p59 protein|peptidyl-prolyl cis-trans isomerase FKBP4|rotamase
|
| Swissprots |
Q9TRX9 Q9TRY0 Q3T0C4 A5D9B2
|
| Accessions |
DAA29159 Q9TRY0 BC102456 AAI02457 BT030531 ABQ12971 NM_001034322 NP_001029494
|
| Function |
Immunophilin protein with PPIase and co-chaperone activities (By similarity). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90) (By similarity). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments (By similarity). The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening (By similarity). Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000250}. Mitochondrion {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Shuttles from mitochondria to nucleus; colocalizes in mitochondria with the glucocorticoid receptor. {ECO:0000250}.
|
| Top Pathways |
Estrogen signaling pathway
|