| Gene Symbol |
PLA2G2F
|
| Entrez Gene |
64600
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phospholipase A2, group IIF
|
| Other Description |
GIIF sPLA2|group IIF secretory phospholipase A2|phosphatidylcholine 2-acylhydrolase 2F|sPLA2-IIF
|
| Swissprots |
Q8N217 Q9BZM2 Q5R385 Q9H506
|
| Accessions |
EAW94916 Q9BZM2 AF306566 AAG50242 AK093645 BAC04210 BC156847 AAI56848 BM987713 BX647458 XM_006710817 XP_006710880 XM_011541955 XP_011540257 XM_011541956 XP_011540258 NM_022819 NP_073730
|
| Function |
PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Hydrolyzes phosphatidylglycerol versus phosphatidylcholine with a 15-fold preference. {ECO:0000269|PubMed:11112443}.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:11112443}.
|
| Tissue Specificity |
Expressed at high levels in placenta, testis, thymus and at lower levels in heart, kidney, liver and prostate. {ECO:0000269|PubMed:11112443}.
|
| Top Pathways |
Vascular smooth muscle contraction, Pancreatic secretion, Fat digestion and absorption, Ether lipid metabolism, Glycerophospholipid metabolism
|