EPS8

Gene Symbol	EPS8
Entrez Gene	2059
Alt Symbol	DFNB102
Species	Human
Gene Type	protein-coding
Description	epidermal growth factor receptor pathway substrate 8
Other Description	epidermal growth factor receptor kinase substrate 8
Swissprots	A6NMC3 A8KA66 Q12929 Q8N6J0 A8K6W2 B4DX66
Accessions	EAW96354 EAW96355 Q12929 AI219284 AI377466 AK291777 BAF84466 AK292931 BAF85620 AK301834 BAG63278 AK304860 BAG65598 AK316134 BAH14505 AK316239 BAH14610 BC005836 BC030010 AAH30010 BI667617 U12535 AAA62280 XM_005253339 XP_005253396 XM_005253340 XP_005253397 XM_006719057 XP_006719120 XM_011520605 XP_011518907 XM_011520606 XP_011518908 NM_004447 NP_004438
Function	Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac- specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2- dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal fil
Subcellular Location	Cytoplasm, cell cortex {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Cell projection, stereocilium {ECO:0000250, ECO:0000250|UniProtKB:Q08509}. Cell junction, synapse, synaptosome {ECO:0000250}. Note=Localizes at the tips of the stereocilia of the inner and outer hair cells (By similarity). Localizes to the midzone of dividing cells. {ECO:0000250, ECO:0000250|UniProtKB:Q08509}.
Tissue Specificity	Expressed in all tissues analyzed, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in all epithelial and fibroblastic lines examined and in some, but not all, hematopoietic cells.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human EPS8 full length protein - ab132240 from Abcam Category Protein Source Wheat germ Species Human

Human EPS8 peptide - ab45513 from Abcam Category Peptide Species Human

EPS8 Antibody Blocking Peptide - LS-E19724 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EPS8 Antibody Blocking Peptide - LS-E25597 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EPS8 Antibody Blocking Peptide - LS-E9534 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Eps8 Protein - H00002059-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Eps8 Peptide - P3176 from Novus Biologicals Category Peptide Species Human

EPS8-Antibody-N-term-Blocking-Peptide - BP8148a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EPS8 blocking peptide - GTX89748-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

EPS8 Blocking Peptide - 33R-9810 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

EPS8 Peptide - AC21-0427-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

EPS8 - H00002059-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

EPS8 - H00002059-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

EPS8 Peptide - 45-548P from ProSci Category Peptide Prices $175.00 Sizes 100 µg

EPS8 fusion protein - Ag3121 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human EPS8, GST-tagged - EPS8-12506H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human EPS8 - EPS8-467H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Human Epidermal growth factor receptor kinase substrate 8(EPS8) ,partial - CSB-YP615539HU CSB-EP615539HU CSB-BP615539HU CSB-MP615539HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

EPS8 - TP305300 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

EPS8, Peptide - MBS426831 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Pig

Eps8 Recombinant Protein Antigen - NBP1-86150PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

EPS8-Antibody-C-term-Blocking-Peptide - BP8148b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EPS8 Peptide, Human - M34GP05014H from Creative Peptides Category Peptide Source Synthetic. Species Human

Epidermal growth factor receptor kinase substrate 8 (EPS8), partial, Recombinant Protein - MBS1449851 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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