| Gene Symbol |
L3MBTL2
|
| Entrez Gene |
83746
|
| Alt Symbol |
H-l(3)mbt-l, L3MBT
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
l(3)mbt-like 2 (Drosophila)
|
| Other Description |
H-l(3)mbt-like protein 2|L(3)mbt-like protein 2|lethal(3)malignant brain tumor-like protein 2
|
| Swissprots |
Q9BQI2 Q96SC4 Q8TEN1 Q969R5 Q9UGS4
|
| Accessions |
EAW60410 EAW60411 EAW60412 EAW60413 EAW60414 EAW60415 EAW60416 Q969R5 AJ305226 CAC37794 AJ305227 CAC37795 AK056443 BAG51710 AK074091 BAB84917 AK097052 BAC04936 AK307763 AL136564 CAB66499 AM392807 CAL37685 AM393641 CAL38517 BC017191 AAH17191 BU184979 CR456482 CAG30368 CU013032 CAK54463 CU013320 CAK54762 DQ576322 DQ892312 ABM83238 DQ895512 ABM86438 XM_011530420 XP_011528722 XM_011530421 XP_011528723 XR_937933 NM_001003689 NM_031488 NP_113676
|
| Function |
Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. {ECO:0000269|PubMed:19233876}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
![Western Blot: L3MBTL2 Overexpression Lysate (Adult Normal) [NBP2-06118] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for L3MBTL2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/15042_L3MBTL2%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-06118-img0001.jpg)