| Gene Symbol | CYP46A1 |
|---|---|
| Entrez Gene | 10858 |
| Alt Symbol | CP46, CYP46 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cytochrome P450, family 46, subfamily A, polypeptide 1 |
| Other Description | CH24H|cholesterol 24-hydroxylase|cytochrome P450 46A1|cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase) |
| Swissprots | Q9Y6A2 E7EQG9 Q8N2B0 B4DHP8 |
| Accessions | EAW81678 Q9Y6A2 AB209749 BAD92986 AF094480 AAD41244 AK090886 BAC03539 AK295216 BAG58210 BC022539 AAH22539 XM_005267274 XP_005267331 XM_011536364 XP_011534666 XM_011536365 XP_011534667 NM_006668 NP_006659 |
| Function | Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol. Has also activity with xenobiotic compounds, such as clotrimazole. {ECO:0000269|PubMed:18621681, ECO:0000269|PubMed:20667828}. |
| Subcellular Location | Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein. |
| Tissue Specificity | Expressed in brain. The mRNA was broadly distributed with higher levels in gray matter zones and lower levels in regions rich in white matter. Not detected in fetal sample but its expression increases linearly with age. |
| Top Pathways | Primary bile acid biosynthesis |