| Gene Symbol | CSNK1A1 |
|---|---|
| Entrez Gene | 1452 |
| Alt Symbol | CK1, CK1a, CKIa, HEL-S-77p, HLCDGP1, PRO2975 |
| Species | Human |
| Gene Type | protein-coding |
| Description | casein kinase 1, alpha 1 |
| Other Description | CKI-alpha|casein kinase I isoform alpha|clock regulator kinase|down-regulated in lung cancer|epididymis secretory sperm binding protein Li 77p |
| Swissprots | Q5U047 Q9UDK3 Q6FGA2 Q5U046 Q71TU5 Q4JJA0 D3DQG0 P48729 Q96HD2 D3DQG1 |
| Accessions | EAW61767 EAW61768 EAW61769 EAW61770 EAW61771 EAW61772 EAW61773 EAW61774 EAW61775 EAW61776 P48729 AF119911 AAF69665 AF218004 AAG17246 AF447582 AAL60204 AK293761 BAG57180 AK294099 BAG57435 AK294942 BAG58018 AK303794 BAG64751 AL701526 BC005905 BC007246 AAH07246 BC008717 AAH08717 BC009186 BC020446 BC020745 BC021971 AAH21971 BC025371 AAH25371 BC040473 BC105984 BT019829 AAV38632 BT019830 AAV38633 BU618830 BX647478 BX648552 CR542206 CAG47002 DA144898 DQ082865 AAY84562 EU668329 ACF94482 HY119498 L37042 AAC41760 X80693 CAA56710 NM_001025105 NP_001020276 NM_001271741 NP_001258670 NM_001271742 NP_001258671 NM_001892 NP_001883 |
| Function | Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. {ECO:0000269|PubMed:11955436, ECO:0000269|PubMed:1409656, ECO:0000269|PubMed:18305108}. |
| Subcellular Location | Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Nucleus speckle. Note=Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. |
| Top Pathways | Wnt signaling pathway, Hedgehog signaling pathway |