CSNK1A1

Gene Symbol CSNK1A1
Entrez Gene 1452
Alt Symbol CK1, CK1a, CKIa, HEL-S-77p, HLCDGP1, PRO2975
Species Human
Gene Type protein-coding
Description casein kinase 1, alpha 1
Other Description CKI-alpha|casein kinase I isoform alpha|clock regulator kinase|down-regulated in lung cancer|epididymis secretory sperm binding protein Li 77p
Swissprots Q5U047 Q9UDK3 Q6FGA2 Q5U046 Q71TU5 Q4JJA0 D3DQG0 P48729 Q96HD2 D3DQG1
Accessions EAW61767 EAW61768 EAW61769 EAW61770 EAW61771 EAW61772 EAW61773 EAW61774 EAW61775 EAW61776 P48729 AF119911 AAF69665 AF218004 AAG17246 AF447582 AAL60204 AK293761 BAG57180 AK294099 BAG57435 AK294942 BAG58018 AK303794 BAG64751 AL701526 BC005905 BC007246 AAH07246 BC008717 AAH08717 BC009186 BC020446 BC020745 BC021971 AAH21971 BC025371 AAH25371 BC040473 BC105984 BT019829 AAV38632 BT019830 AAV38633 BU618830 BX647478 BX648552 CR542206 CAG47002 DA144898 DQ082865 AAY84562 EU668329 ACF94482 HY119498 L37042 AAC41760 X80693 CAA56710 NM_001025105 NP_001020276 NM_001271741 NP_001258670 NM_001271742 NP_001258671 NM_001892 NP_001883
Function Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. {ECO:0000269|PubMed:11955436, ECO:0000269|PubMed:1409656, ECO:0000269|PubMed:18305108}.
Subcellular Location Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Nucleus speckle. Note=Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis.
Top Pathways Wnt signaling pathway, Hedgehog signaling pathway

CK1 Antibody - 2655 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of lysates from various cell lines using Casein Kinase I Antibody.

casein kinase Iα (C-19) - sc-6477 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
casein kinase Iα siRNA (h): sc-29912. Immunofluorescence staining of methanol-fixed, control HeLa (A) and casein kinase Iα siRNA silenced HeLa (B) cells showing diminished cytoplasmic staining in the siRNA silenced cells. Cells probed with casein kinase Iα (C-19): sc-6477.

casein kinase Iα (D-9) - sc-74583 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
casein kinase Iα (D-9): sc-74583. Western blot analysis of casein kinase Iα expression in non-transfected (A) and human casein kinase Iα transfected (B) 293 whole cell lysates.

casein kinase Iα (H-7) - sc-74582 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
casein kinase Iα (H-7): sc-74582. Western blot analysis of casein kinase Iα expression in BJAB (A), HeLa (B) and KNRK (C) whole cell lysates.

casein kinase Iα (N-19) - sc-6478 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
casein kinase Iα (N-19): sc-6478. Western blot analysis of casein kinase Iα expression in BJAB (A) and K-562 (B) whole cell lysates.

casein kinase Iα (H-57) - sc-28886 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
casein kinase Iα sc-28886. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

Anti-Casein Kinase 1 alpha (phospho T1194) antibody - ab63559 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Casein Kinase 1 alpha (phospho T1194) antibody (ab63559) at 1/500 dilutionLane 1 : extracts from HuvEc cellsLane 2 : extracts from HuvEc cells with immunizing phosphopeptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-Casein Kinase 1 alpha (phospho Y294) antibody - ab192650 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Casein Kinase 1 alpha (phospho Y294) antibody (ab192650) at 1/500 dilutionLane 1 : HT29 cell extract treated with heat shockLane 2 : HT29 cell extract treated with heat shock with antigen-specific peptide

Anti-Casein Kinase 1 alpha (phospho Y294) antibody - ab138375 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Casein Kinase 1 alpha (phospho Y294) antibody (ab138375) at 1/500 dilution + HT29 cell extract treated with heat shock at 10 µg

Anti-Casein Kinase 1 alpha antibody - ab63373 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Casein Kinase 1 alpha antibody (ab63373) at 1/500 dilutionLane 1 : HUVEC cell extractLane 2 : K562 cell extractLane 3 : Peptide blocking experiment, K562 LysateLysates/proteins at 30 µg per lane.

Anti-Casein Kinase 1 alpha antibody - ab71692 from Abcam

Prices $378.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Casein Kinase 1 alpha antibody (ab71692) at 1/100 dilution + A375 cell lysate at 12.5 µgSecondaryHRP-anti-rabbit

Anti-Casein Kinase 1 alpha antibody - ab95272 from Abcam

Prices $376.00
Sizes 100 µl
Host Chicken
Clonality Polyclonal
ab95272, at a 1/1000 dilution, staining HeLa cells (red). Blue is the Hoeschst DNA stain.

Anti-Casein Kinase 1 alpha antibody - ab136052 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Casein Kinase 1 alpha antibody (ab136052) at 1/500 dilution + HT29 cell lysates at 30 µg

Anti-Casein Kinase 1 alpha antibody [AT2E2] - ab88079 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone AT2E2
All lanes : Anti-Casein Kinase 1 alpha antibody [AT2E2] (ab88079) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : MCF7 cell lysateLysates/proteins at 40 µg per lane.SecondaryHRP conjugated goat anti-mouse IgGdeveloped using the ECL technique

Anti-Casein Kinase 1 alpha antibody [EPR1961(2)] - ab108296 from Abcam

Prices $381.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1961(2)
All lanes : Anti-Casein Kinase 1 alpha antibody [EPR1961(2)] (ab108296) at 1/1000 dilutionLane 1 : MCF7 cell lysateLane 2 : HeLa cell lysateLane 3 : Jurkat cell lysateLane 4 : HT-1376 cell lysateLysates/proteins at 10 µg per lane.

Anti-CSNK1A1 / CK1 Alpha Antibody IHC-plus™ - LS-B10375 from LifeSpan Bioscience

Host Chicken
Clonality Polyclonal
Anti-CSNK1A1 / CK1 Alpha antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10375 dilution 1:500.

Anti-CSNK1A1 / CK1 Alpha Antibody (aa114-324) - LS-C294056 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of recombinant CSNK1A1 / CK1 Alpha.

Anti-CSNK1A1 / CK1 Alpha Antibody - LS-C77824 from LifeSpan Bioscience

Host Sheep
Clonality Polyclonal

Anti-CSNK1A1 / CK1 Alpha Antibody (clone AT2E2) - LS-C103485 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone AT2E2

Anti-CSNK1A1 / CK1 Alpha Antibody (aa1-337) - LS-C127255 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-CSNK1A1 / CK1 Alpha Antibody (aa310-327) - LS-C195912 from LifeSpan Bioscience

Host Goat
Clonality Polyclonal

Anti-CSNK1A1 / CK1 Alpha Antibody (aa28-77) - LS-C151270 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
CSNK1A1 / CK1 Alpha antibody Western Blot of Rat Thymus.

Anti-CSNK1A1 / CK1 Alpha Antibody (Internal, clone EPR1961(2)) - LS-C138506 from LifeSpan Bioscience

Host Rabbit
Clonality Monoclonal
Clone [EPR1961(2)]
Western blot analysis on (A) MCF-7, (B) HeLa, (C) Jurkat, and (D) HT-1376 cell lysates using anti-Casein Kinase I antibody.

Anti-CSNK1A1 / CK1 Alpha Antibody (aa287-336) - LS-C118022 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Immunofluorescence of HeLa cells, using CKI-alpha (Ab-321) Antibody. The picture on the right is treated with the synthesized peptide.

Anti-CSNK1A1 / CK1 Alpha Antibody (C-Terminus) - LS-C81669 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
293T cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.
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