| Gene Symbol |
Rab23
|
| Entrez Gene |
19335
|
| Alt Symbol |
AW545388, opb, opb2
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
RAB23, member RAS oncogene family
|
| Other Description |
open brain 2|protein open brain|rab-15|ras-related protein Rab-23
|
| Swissprots |
P35288
|
| Accessions |
EDL14436 EDL14437 P35288 AB232618 BAF02880 AK016493 BAB30270 AK019666 AK045454 AK047068 BAC32949 AK054079 AK082017 AK163909 AK164057 AK219428 BC025578 AAH25578 M79305 AAK14829 Z22821 CAA80474 XM_006495801 XP_006495864 XM_006495802 XP_006495865 NM_001159729 NP_001153201 NM_008999 NP_033025
|
| Function |
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes (By similarity). Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. {ECO:0000250, ECO:0000269|PubMed:11071781, ECO:0000269|PubMed:11449277, ECO:0000269|PubMed:16364285, ECO:0000269|PubMed:18218620, ECO:0000269|Pu
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm. Cell membrane. Endosome membrane. Cytoplasmic vesicle, autophagosome {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Recruited to phagosomes containing S.aureus or Mycobacterium. {ECO:0000250}.
|
| Tissue Specificity |
Detected in brain neurons (at protein level). Forebrain and midbrain. {ECO:0000269|PubMed:14617350, ECO:0000269|PubMed:16463280}.
|
| Top Pathways |
Hedgehog signaling pathway
|