Gene Symbol | Pla2g1b |
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Entrez Gene | 18778 |
Alt Symbol | Pla2a, sPLA2IB |
Species | Mouse |
Gene Type | protein-coding |
Description | phospholipase A2, group IB, pancreas |
Other Description | PLA2-Ib|group IB phospholipase A2|phosphatidylcholine 2-acylhydrolase 1B|phospholipase A2 |
Swissprots | Q9D7E2 Q9D884 A6H6K5 Q9Z0Y2 |
Accessions | AAF02298 EDL19858 Q9Z0Y2 AF094610 AAG27064 AF097637 AAD19896 AF162712 AAD45806 AF187852 AAF44297 AK007730 BAB25218 AK007797 BAB25263 AK008331 BAB25608 AK008664 BAB25819 AK008668 BAB25822 AK008841 BAB25922 AK008934 BAB25976 AK008936 BAB25978 AK009314 BAB26212 AK019009 AK028104 BAC25749 AK028134 BAC25763 BC145546 BC145908 AAI45909 BC145910 AAI45911 XM_006530199 XP_006530262 NM_011107 NP_035237 |
Function | PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules. |
Subcellular Location | Secreted. Note=secreted from pancreatic acinar cells in its inactive form. {ECO:0000250}. |
Top Pathways | Vascular smooth muscle contraction, Pancreatic secretion, Fat digestion and absorption, Ether lipid metabolism, Glycerophospholipid metabolism |
group IB sPLA 2 CRISPR/Cas9 KO Plasmid (m) - sc-422279 from Santa Cruz Biotechnology
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group IB sPLA 2 HDR Plasmid (m) - sc-422279-HDR from Santa Cruz Biotechnology
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group IB sPLA 2 Double Nickase Plasmid (m) - sc-422279-NIC from Santa Cruz Biotechnology
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group IB sPLA 2 Double Nickase Plasmid (m2) - sc-422279-NIC-2 from Santa Cruz Biotechnology
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group IB sPLA 2 CRISPR Activation Plasmid (m) - sc-422279-ACT from Santa Cruz Biotechnology
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group IB sPLA 2 CRISPR Activation Plasmid (m2) - sc-422279-ACT-2 from Santa Cruz Biotechnology
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group IB sPLA 2 Lentiviral Activation Particles (m) - sc-422279-LAC from Santa Cruz Biotechnology
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group IB sPLA 2 Lentiviral Activation Particles (m2) - sc-422279-LAC-2 from Santa Cruz Biotechnology
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group IB sPLA 2 siRNA (m) - sc-145770 from Santa Cruz Biotechnology
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group IB sPLA2 shRNA Plasmid (m) - sc-145770-SH from Santa Cruz Biotechnology
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group IB sPLA2 shRNA (m) Lentiviral Particles - sc-145770-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU048901 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN38817 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND38817 from Sigma-Aldrich
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PLA2G1B siRNA (Mouse) - CRM3101 from Cohesion Biosciences
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shRNA set against Mouse PLA2G1B (NM_011107.1) - SHH376728 from Creative biogene
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shRNA set against Mouse Pla2g1b(NM_011107.1) - SHR118740 from Creative biogene
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Mouse PLA2G1B siRNA - orb282577 from Biorbyt
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PLA2G1B shRNA Plasmid (Mouse) - CHM3101 from Cohesion Biosciences
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PLA2G1B miRNA 3'UTR clone - MiUTR1M-09279 from Creative biogene
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