Gene Symbol | ATIC |
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Entrez Gene | 471 |
Alt Symbol | AICAR, AICARFT, HEL-S-70p, IMPCHASE, PURH |
Species | Human |
Gene Type | protein-coding |
Description | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase |
Other Description | 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleotide transformylase/inosinicase|AICAR formyltransferase/IMP cyclohydrolase bifunctional enzyme|AICARFT/IMPCHASE|bifunctional purine biosynthesis protein PURH|epididymis secretory sperm binding protein Li 70p|phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase |
Swissprots | Q13856 P31939 E9PBU3 A8K202 Q53S28 |
Accessions | AAY24062 EAW70523 EAW70524 EAW70525 EAW70526 EAW70527 EAW70528 EAW70529 P31939 AA494525 AB062403 BAB93490 AK290067 BAF82756 AK298142 BAG60418 AK313066 BAG35895 BC008879 AAH08879 D82348 BAA11559 D89976 BAA21762 DA043224 DA074758 DQ893262 ABM84188 DQ896591 ABM87590 EU794654 ACJ13708 U37436 AAA97405 NM_004044 NP_004035 |
Function | Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis. {ECO:0000269|PubMed:14966129}. |
Top Pathways | Purine metabolism, One carbon pool by folate |
AICAR CRISPR/Cas9 KO Plasmid (h) - sc-404771 from Santa Cruz Biotechnology
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AICAR HDR Plasmid (h) - sc-404771-HDR from Santa Cruz Biotechnology
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AICAR Double Nickase Plasmid (h) - sc-404771-NIC from Santa Cruz Biotechnology
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AICAR Double Nickase Plasmid (h2) - sc-404771-NIC-2 from Santa Cruz Biotechnology
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AICAR CRISPR Activation Plasmid (h) - sc-404771-ACT from Santa Cruz Biotechnology
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AICAR CRISPR Activation Plasmid (h2) - sc-404771-ACT-2 from Santa Cruz Biotechnology
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AICAR Lentiviral Activation Particles (h) - sc-404771-LAC from Santa Cruz Biotechnology
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AICAR Lentiviral Activation Particles (h2) - sc-404771-LAC-2 from Santa Cruz Biotechnology
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AICAR transformylase siRNA (h) - sc-60139 from Santa Cruz Biotechnology
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AICAR transformylase shRNA Plasmid (h) - sc-60139-SH from Santa Cruz Biotechnology
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AICAR transformylase shRNA (h) Lentiviral Particles - sc-60139-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU055141 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3659 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3659 from Sigma-Aldrich
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ATIC siRNA (Human) - CRH0327 from Cohesion Biosciences
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ATIC - MBS8239726 from MyBioSource
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shRNA set against Human ATIC (NM_004044.6) - SHH242234 from Creative biogene
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Human ATIC siRNA - orb260829 from Biorbyt
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ATIC shRNA Plasmid (Human) - CHH0327 from Cohesion Biosciences
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ATIC miRNA 3'UTR clone - MiUTR3H-04355 from Creative biogene
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