| Gene Symbol | TUSC3 |
|---|---|
| Entrez Gene | 7991 |
| Alt Symbol | D8S1992, M33, MRT22, MRT7, N33, OST3A |
| Species | Human |
| Gene Type | protein-coding |
| Description | tumor suppressor candidate 3 |
| Other Description | Putative prostate cancer tumor suppressor|magnesium uptake/transporter TUSC3|oligosaccharyltransferase 3 homolog A |
| Swissprots | D3DSP2 Q14912 A8MSM0 Q13454 Q96FW0 Q14911 |
| Accessions | AAB18375 AAB18376 EAW63837 EAW63838 EAW63839 Q13454 AF028729 AI366810 AK026149 AY530159 AAS18677 AY562998 AAS75588 AY562999 AAS75589 BC010370 AAH10370 BT020002 AAV38805 BX641112 DA796279 DQ892936 ABM83862 DQ896185 ABM87184 U42349 AAB18374 XM_011544651 XP_011542953 XM_011544652 XP_011542954 XM_011544653 XP_011542955 XM_011544654 XP_011542956 NM_006765 NP_006756 NM_178234 NP_839952 |
| Function | Magnesium transporter (PubMed:19717468). May be involved in N-glycosylation through its association with N-oligosaccharyl transferase (PubMed:24685145). {ECO:0000269|PubMed:19717468, ECO:0000303|PubMed:12887896, ECO:0000303|PubMed:24685145}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Tissue Specificity | Expressed in most non-lymphoid cells and tissues examined, including prostate, lung, liver, colon, heart, kidney and pancreas. {ECO:0000269|PubMed:12887896}. |
| Top Pathways | N-Glycan biosynthesis, Protein processing in endoplasmic reticulum |