Gene Symbol | TUSC3 |
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Entrez Gene | 7991 |
Alt Symbol | D8S1992, M33, MRT22, MRT7, N33, OST3A |
Species | Human |
Gene Type | protein-coding |
Description | tumor suppressor candidate 3 |
Other Description | Putative prostate cancer tumor suppressor|magnesium uptake/transporter TUSC3|oligosaccharyltransferase 3 homolog A |
Swissprots | D3DSP2 Q14912 A8MSM0 Q13454 Q96FW0 Q14911 |
Accessions | AAB18375 AAB18376 EAW63837 EAW63838 EAW63839 Q13454 AF028729 AI366810 AK026149 AY530159 AAS18677 AY562998 AAS75588 AY562999 AAS75589 BC010370 AAH10370 BT020002 AAV38805 BX641112 DA796279 DQ892936 ABM83862 DQ896185 ABM87184 U42349 AAB18374 XM_011544651 XP_011542953 XM_011544652 XP_011542954 XM_011544653 XP_011542955 XM_011544654 XP_011542956 NM_006765 NP_006756 NM_178234 NP_839952 |
Function | Magnesium transporter (PubMed:19717468). May be involved in N-glycosylation through its association with N-oligosaccharyl transferase (PubMed:24685145). {ECO:0000269|PubMed:19717468, ECO:0000303|PubMed:12887896, ECO:0000303|PubMed:24685145}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
Tissue Specificity | Expressed in most non-lymphoid cells and tissues examined, including prostate, lung, liver, colon, heart, kidney and pancreas. {ECO:0000269|PubMed:12887896}. |
Top Pathways | N-Glycan biosynthesis, Protein processing in endoplasmic reticulum |
TUSC3 CRISPR/Cas9 KO Plasmid (h) - sc-405571 from Santa Cruz Biotechnology
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TUSC3 HDR Plasmid (h) - sc-405571-HDR from Santa Cruz Biotechnology
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TUSC3 Double Nickase Plasmid (h) - sc-405571-NIC from Santa Cruz Biotechnology
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TUSC3 Double Nickase Plasmid (h2) - sc-405571-NIC-2 from Santa Cruz Biotechnology
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TUSC3 CRISPR Activation Plasmid (h) - sc-405571-ACT from Santa Cruz Biotechnology
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TUSC3 CRISPR Activation Plasmid (h2) - sc-405571-ACT-2 from Santa Cruz Biotechnology
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TUSC3 Lentiviral Activation Particles (h) - sc-405571-LAC from Santa Cruz Biotechnology
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TUSC3 Lentiviral Activation Particles (h2) - sc-405571-LAC-2 from Santa Cruz Biotechnology
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TUSC3 siRNA (h) - sc-77535 from Santa Cruz Biotechnology
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TUSC3 shRNA Plasmid (h) - sc-77535-SH from Santa Cruz Biotechnology
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TUSC3 shRNA (h) Lentiviral Particles - sc-77535-V from Santa Cruz Biotechnology
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TUSC3 RNAi - H00007991-R02 from Novus Biologicals
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MISSION® esiRNA - EHU071981 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22288 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22288 from Sigma-Aldrich
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TUSC3 siRNA (Human) - CRH5335 from Cohesion Biosciences
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TUSC3 RNAi - H00007991-R01 from Novus Biologicals
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TUSC3 - MBS8212529 from MyBioSource
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shRNA set against Human TUSC3 (NM_178234.2) - SHH437996 from Creative biogene
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TUSC3 shRNA Plasmid (Human) - CHH5335 from Cohesion Biosciences
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TUSC3 miRNA 3'UTR clone - MiUTR3H-04085 from Creative biogene
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TUSC3 miRNA 3'UTR clone - MiUTR3H-04086 from Creative biogene
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